Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women
BackgroundThe prevalence, persistence, and multiplicity of human papillomavirus (HPV) infection appears different comparing HIV-positive to HIV-negative women. In this study, we examined prevalent, persistent, and multiple low- and high-risk cervical HPV infections in HIV-negative and HIV-positive w...
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| Format: | Article |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpubh.2017.00178/full |
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| author | Sally N. Adebamowo Sally N. Adebamowo Sally N. Adebamowo Oluwatoyosi Olawande Ayotunde Famooto Ayotunde Famooto Eileen O. Dareng Richard Offiong Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo for the H3Africa ACCME Research Group |
| author_facet | Sally N. Adebamowo Sally N. Adebamowo Sally N. Adebamowo Oluwatoyosi Olawande Ayotunde Famooto Ayotunde Famooto Eileen O. Dareng Richard Offiong Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo for the H3Africa ACCME Research Group |
| author_sort | Sally N. Adebamowo |
| collection | DOAJ |
| description | BackgroundThe prevalence, persistence, and multiplicity of human papillomavirus (HPV) infection appears different comparing HIV-positive to HIV-negative women. In this study, we examined prevalent, persistent, and multiple low- and high-risk cervical HPV infections in HIV-negative and HIV-positive women.MethodsWe studied 1,020 women involved in a study of HPV infection using SPF25/LiPA10. Two study visits were scheduled, at enrollment and 6 months afterward. At each study visit, research nurses used a cervical brush to collect samples of exfoliated cervical cells from the cervical os, from all the study participants. Exact logistic regression models were used to estimate associations between HIV and HPV infections.ResultsThe mean (SD) age of the study participants was 38 (8) years, 56% were HIV-negative and 44% were HIV-positive. Among HIV-negative women at baseline, single low-risk HPV (lrHPV) infections occurred in 12%; multiple lrHPV in 2%; single high-risk human papillomavirus (hrHPV) infections in 9%, and multiple hrHPV infections in 2%. Single lrHPV infections were persistent in 6%, but there was no persistent multiple lrHPV infections. Single hrHPV infections were persistent in 4% while multiple hrHPV infections were persistent in 0.3%. Among HIV-positive women at baseline, single lrHPV infections occurred in 19%, multiple lrHPV in 6%, single hrHPV infections in 17%, and multiple hrHPV infections occurred in 12%. Single lrHPV infections were persistent in 9%, multiple lrHPV infections in 0.6%, single hrHPV infections in 13%, while multiple hrHPV were persistent in 3%. Prevalent, persistent, and multiple infections were more common in HIV-positive women, compared to HIV-negative women. In multivariate models adjusted for age, marital status, socioeconomic status, age at sexual initiation, and douching, the odds ratios comparing HIV-positive to HIV-negative women, were 2.09 (95% CI 1.47–2.97, p < 0.001) for prevalent lrHPV, 1.26 (95% CI 0.66–2.40, p 0.47) for persistent lrHPV infections, 3.38 (95% CI 2.34–4.87, p < 0.001) for prevalent hrHPV, and 4.49 (95% CI 2.26–8.91, p < 0.001) for persistent hrHPV infections.ConclusionHIV infection was associated with higher prevalence of lrHPV, hrHPV, and persistence hrHPV infections, but not persistent lrHPV infections. |
| first_indexed | 2024-04-13T09:17:39Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T09:17:39Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-5b873d1d5ffc414bbe99ae78a30dadec2022-12-22T02:52:41ZengFrontiers Media S.A.Frontiers in Public Health2296-25652017-07-01510.3389/fpubh.2017.00178271323Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive WomenSally N. Adebamowo0Sally N. Adebamowo1Sally N. Adebamowo2Oluwatoyosi Olawande3Ayotunde Famooto4Ayotunde Famooto5Eileen O. Dareng6Richard Offiong7Clement A. Adebamowo8Clement A. Adebamowo9Clement A. Adebamowo10Clement A. Adebamowo11for the H3Africa ACCME Research Group12Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United StatesUniversity of Maryland Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, United StatesCenter for Bioethics and Research, Ibadan, NigeriaOffice of Strategic Information and Research, Institute of Human Virology Nigeria, Abuja, NigeriaCenter for Bioethics and Research, Ibadan, NigeriaOffice of Strategic Information and Research, Institute of Human Virology Nigeria, Abuja, NigeriaDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United KingdomDepartment of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, NigeriaDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United StatesUniversity of Maryland Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, United StatesCenter for Bioethics and Research, Ibadan, NigeriaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, United StatesInstitute of Human Virology Nigeria, Abuja, NigeriaBackgroundThe prevalence, persistence, and multiplicity of human papillomavirus (HPV) infection appears different comparing HIV-positive to HIV-negative women. In this study, we examined prevalent, persistent, and multiple low- and high-risk cervical HPV infections in HIV-negative and HIV-positive women.MethodsWe studied 1,020 women involved in a study of HPV infection using SPF25/LiPA10. Two study visits were scheduled, at enrollment and 6 months afterward. At each study visit, research nurses used a cervical brush to collect samples of exfoliated cervical cells from the cervical os, from all the study participants. Exact logistic regression models were used to estimate associations between HIV and HPV infections.ResultsThe mean (SD) age of the study participants was 38 (8) years, 56% were HIV-negative and 44% were HIV-positive. Among HIV-negative women at baseline, single low-risk HPV (lrHPV) infections occurred in 12%; multiple lrHPV in 2%; single high-risk human papillomavirus (hrHPV) infections in 9%, and multiple hrHPV infections in 2%. Single lrHPV infections were persistent in 6%, but there was no persistent multiple lrHPV infections. Single hrHPV infections were persistent in 4% while multiple hrHPV infections were persistent in 0.3%. Among HIV-positive women at baseline, single lrHPV infections occurred in 19%, multiple lrHPV in 6%, single hrHPV infections in 17%, and multiple hrHPV infections occurred in 12%. Single lrHPV infections were persistent in 9%, multiple lrHPV infections in 0.6%, single hrHPV infections in 13%, while multiple hrHPV were persistent in 3%. Prevalent, persistent, and multiple infections were more common in HIV-positive women, compared to HIV-negative women. In multivariate models adjusted for age, marital status, socioeconomic status, age at sexual initiation, and douching, the odds ratios comparing HIV-positive to HIV-negative women, were 2.09 (95% CI 1.47–2.97, p < 0.001) for prevalent lrHPV, 1.26 (95% CI 0.66–2.40, p 0.47) for persistent lrHPV infections, 3.38 (95% CI 2.34–4.87, p < 0.001) for prevalent hrHPV, and 4.49 (95% CI 2.26–8.91, p < 0.001) for persistent hrHPV infections.ConclusionHIV infection was associated with higher prevalence of lrHPV, hrHPV, and persistence hrHPV infections, but not persistent lrHPV infections.http://journal.frontiersin.org/article/10.3389/fpubh.2017.00178/fullhuman papillomavirusHIVNigeriacervical cancerprevalencepersistence and multiple infections |
| spellingShingle | Sally N. Adebamowo Sally N. Adebamowo Sally N. Adebamowo Oluwatoyosi Olawande Ayotunde Famooto Ayotunde Famooto Eileen O. Dareng Richard Offiong Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo Clement A. Adebamowo for the H3Africa ACCME Research Group Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women Frontiers in Public Health human papillomavirus HIV Nigeria cervical cancer prevalence persistence and multiple infections |
| title | Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women |
| title_full | Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women |
| title_fullStr | Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women |
| title_full_unstemmed | Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women |
| title_short | Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women |
| title_sort | persistent low risk and high risk human papillomavirus infections of the uterine cervix in hiv negative and hiv positive women |
| topic | human papillomavirus HIV Nigeria cervical cancer prevalence persistence and multiple infections |
| url | http://journal.frontiersin.org/article/10.3389/fpubh.2017.00178/full |
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