BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics in a range of crucial cellular processes. Whils...

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Bibliographic Details
Main Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Neurodegeneration
Subjects:
BIN1
Alzheimer’s disease
Neuroinflammation
Microglia
Innate immunity
GWAS risk factor
Online Access:https://doi.org/10.1186/s13024-022-00535-x

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