A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms
Since the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/6/509 |
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| author | Lydia Kossiva Athanasios Thirios Eleni Panagouli Alexandros Panos Stavroula Lampidi Flora Bacopoulou Maria Tsolia Artemis Tsitsika |
| author_facet | Lydia Kossiva Athanasios Thirios Eleni Panagouli Alexandros Panos Stavroula Lampidi Flora Bacopoulou Maria Tsolia Artemis Tsitsika |
| author_sort | Lydia Kossiva |
| collection | DOAJ |
| description | Since the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including renal, cardiovascular, circulatory, and respiratory systems, causing chronic obstructive pulmonary disease. We report on a 14-year-old male adolescent, who presented with thrombocytopenia (platelet count 92 × 10<sup>9</sup> /L) and leukopenia (white blood count 4.2 × 10<sup>3</sup> /μL) that was observed two months ago. Ten days before the first blood test, a viral infection with nasal congestion and runny nose was reported, without other accompanying symptoms. Viral antibodies screening revealed positivity for all the three specific COVID-19 antibodies. Further haematological evaluation with bone marrow aspiration revealed non-specific dysplastic features of the red cell and megakaryocyte progenitors. Although haematological alterations due to COVID-19 infection are available from adult patients’ reports, the effect of COVID-19 infection in the pediatric population is underestimated and this is the first case with such haematological involvement. Noteworthy, in the current case, the impact of the COVID-19 infection was not related to the severity of the disease, as the symptoms were mild. In similar cases, bone marrow aspiration would not be performed as a part of routine work-up. Thus, it is important when evaluating pediatric patients with COVID-19 infection to search and report those alterations in order to better understand the impact and the spectrum of clinical manifestations of the specific viral infection in children and adolescents. |
| first_indexed | 2024-03-10T10:21:24Z |
| format | Article |
| id | doaj.art-5b8950fd8d654a7f87634ec29f2bd18d |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T10:21:24Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-5b8950fd8d654a7f87634ec29f2bd18d2023-11-22T00:21:45ZengMDPI AGChildren2227-90672021-06-018650910.3390/children8060509A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild SymptomsLydia Kossiva0Athanasios Thirios1Eleni Panagouli2Alexandros Panos3Stavroula Lampidi4Flora Bacopoulou5Maria Tsolia6Artemis Tsitsika72nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, GreeceCenter for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, “Agia Sophia” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece2nd Department of Pediatrics, “P. & A. Kyriakou” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, GreeceSince the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including renal, cardiovascular, circulatory, and respiratory systems, causing chronic obstructive pulmonary disease. We report on a 14-year-old male adolescent, who presented with thrombocytopenia (platelet count 92 × 10<sup>9</sup> /L) and leukopenia (white blood count 4.2 × 10<sup>3</sup> /μL) that was observed two months ago. Ten days before the first blood test, a viral infection with nasal congestion and runny nose was reported, without other accompanying symptoms. Viral antibodies screening revealed positivity for all the three specific COVID-19 antibodies. Further haematological evaluation with bone marrow aspiration revealed non-specific dysplastic features of the red cell and megakaryocyte progenitors. Although haematological alterations due to COVID-19 infection are available from adult patients’ reports, the effect of COVID-19 infection in the pediatric population is underestimated and this is the first case with such haematological involvement. Noteworthy, in the current case, the impact of the COVID-19 infection was not related to the severity of the disease, as the symptoms were mild. In similar cases, bone marrow aspiration would not be performed as a part of routine work-up. Thus, it is important when evaluating pediatric patients with COVID-19 infection to search and report those alterations in order to better understand the impact and the spectrum of clinical manifestations of the specific viral infection in children and adolescents.https://www.mdpi.com/2227-9067/8/6/509COVID-19leucopeniaplatelet countbone marrowmyelodysplastic syndromes |
| spellingShingle | Lydia Kossiva Athanasios Thirios Eleni Panagouli Alexandros Panos Stavroula Lampidi Flora Bacopoulou Maria Tsolia Artemis Tsitsika A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms Children COVID-19 leucopenia platelet count bone marrow myelodysplastic syndromes |
| title | A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms |
| title_full | A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms |
| title_fullStr | A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms |
| title_full_unstemmed | A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms |
| title_short | A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms |
| title_sort | case of covid 19 related thrombocytopenia and leukopenia in an adolescent with mild symptoms |
| topic | COVID-19 leucopenia platelet count bone marrow myelodysplastic syndromes |
| url | https://www.mdpi.com/2227-9067/8/6/509 |
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