Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies
Skeletal muscles are the agent of motion and one of the most important tissues responsible for the control of metabolism. The maintenance of muscle homeostasis is finely regulated by the balance between catabolic and anabolic process. Macroautophagy (or autophagy) is a catabolic process that provide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-07-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/1/3/325 |
| _version_ | 1797713888036257792 |
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| author | Paolo Bonaldo Paolo Grumati |
| author_facet | Paolo Bonaldo Paolo Grumati |
| author_sort | Paolo Bonaldo |
| collection | DOAJ |
| description | Skeletal muscles are the agent of motion and one of the most important tissues responsible for the control of metabolism. The maintenance of muscle homeostasis is finely regulated by the balance between catabolic and anabolic process. Macroautophagy (or autophagy) is a catabolic process that provides the degradation of protein aggregation and damaged organelles through the fusion between autophagosomes and lysosomes. Proper regulation of the autophagy flux is fundamental for the homeostasis of skeletal muscles during physiological situations and in response to stress. Defective as well as excessive autophagy is harmful for muscle health and has a pathogenic role in several forms of muscle diseases. This review will focus on the role of autophagy in muscle homeostasis and diseases. |
| first_indexed | 2024-03-12T07:43:31Z |
| format | Article |
| id | doaj.art-5b8b516752544c9b9f326d2f2d7c508e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:43:31Z |
| publishDate | 2012-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5b8b516752544c9b9f326d2f2d7c508e2023-09-02T21:06:15ZengMDPI AGCells2073-44092012-07-011332534510.3390/cells1030325Autophagy in Skeletal Muscle Homeostasis and in Muscular DystrophiesPaolo BonaldoPaolo GrumatiSkeletal muscles are the agent of motion and one of the most important tissues responsible for the control of metabolism. The maintenance of muscle homeostasis is finely regulated by the balance between catabolic and anabolic process. Macroautophagy (or autophagy) is a catabolic process that provides the degradation of protein aggregation and damaged organelles through the fusion between autophagosomes and lysosomes. Proper regulation of the autophagy flux is fundamental for the homeostasis of skeletal muscles during physiological situations and in response to stress. Defective as well as excessive autophagy is harmful for muscle health and has a pathogenic role in several forms of muscle diseases. This review will focus on the role of autophagy in muscle homeostasis and diseases.http://www.mdpi.com/2073-4409/1/3/325autophagyskeletal muscledystrophy |
| spellingShingle | Paolo Bonaldo Paolo Grumati Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies Cells autophagy skeletal muscle dystrophy |
| title | Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies |
| title_full | Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies |
| title_fullStr | Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies |
| title_full_unstemmed | Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies |
| title_short | Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies |
| title_sort | autophagy in skeletal muscle homeostasis and in muscular dystrophies |
| topic | autophagy skeletal muscle dystrophy |
| url | http://www.mdpi.com/2073-4409/1/3/325 |
| work_keys_str_mv | AT paolobonaldo autophagyinskeletalmusclehomeostasisandinmusculardystrophies AT paologrumati autophagyinskeletalmusclehomeostasisandinmusculardystrophies |