Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study
Purpose: To assess fronto-temporal connectivity in never-medicated patients with first episode schizophrenia (FES). Material and methods: Twelve never-medicated patients (median age = 25.5 y) with first episode schizophrenia (according to DSM-IV system) and sixteen demographically matched controls w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-03-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X15002569 |
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| author | Shaimaa Abdelsattar Mohammad Hossam Moussa Sakr Sameh Mohamed Yousri Bondok Dalia Abdel Moneim Mahmoud Hanan M.E. Azzam Safeya Effat |
| author_facet | Shaimaa Abdelsattar Mohammad Hossam Moussa Sakr Sameh Mohamed Yousri Bondok Dalia Abdel Moneim Mahmoud Hanan M.E. Azzam Safeya Effat |
| author_sort | Shaimaa Abdelsattar Mohammad |
| collection | DOAJ |
| description | Purpose: To assess fronto-temporal connectivity in never-medicated patients with first episode schizophrenia (FES).
Material and methods: Twelve never-medicated patients (median age = 25.5 y) with first episode schizophrenia (according to DSM-IV system) and sixteen demographically matched controls were enrolled in the study. Conventional MRI sequences were obtained. Single shot echo-planar DTI was acquired in 32 non-collinear directions. Tractography of the direct pathway of the superior longitudinal fasciculus (SLFd) and uncinate fasciculus of both hemispheres was performed, and ROIs at the anterior cingulum and external capsule of both hemispheres were drawn. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD) and Trace of the ROIs and reconstructed tracts were calculated. Group comparison was performed using independent sample t-test and Fisher’s exact test.
Results: Compared to healthy participants, there was significant reduction of FA of the left external capsule (p = 0.001) with increase in RD and Trace (p = .004, .048 respectively). However, the right SLFd showed significant reduction of AD (p = 0.005) and the left SLFd showed significant reduction of its volume (p = 0.02).
Conclusion: In patients with FES, impaired white matter connectivity was recognized in the right SLFd and left external capsule associated with reduction in the volume of the left SLFd. |
| first_indexed | 2024-12-22T20:15:03Z |
| format | Article |
| id | doaj.art-5b8bd869304949e58d1858f1e9ff404f |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-22T20:15:03Z |
| publishDate | 2016-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-5b8bd869304949e58d1858f1e9ff404f2022-12-21T18:13:58ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-03-0147125526210.1016/j.ejrnm.2015.11.012Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI studyShaimaa Abdelsattar Mohammad0Hossam Moussa Sakr1Sameh Mohamed Yousri Bondok2Dalia Abdel Moneim Mahmoud3Hanan M.E. Azzam4Safeya Effat5Department of Radiodiagnosis, Faculty of Medicine, Ain-Shams University, Ramsis st. Abbasia, Cairo, EgyptDepartment of Radiodiagnosis, Faculty of Medicine, Ain-Shams University, Ramsis st. Abbasia, Cairo, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Ain-Shams University, Cairo, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Ain-Shams University, Cairo, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Ain-Shams University, Cairo, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Ain-Shams University, Cairo, EgyptPurpose: To assess fronto-temporal connectivity in never-medicated patients with first episode schizophrenia (FES). Material and methods: Twelve never-medicated patients (median age = 25.5 y) with first episode schizophrenia (according to DSM-IV system) and sixteen demographically matched controls were enrolled in the study. Conventional MRI sequences were obtained. Single shot echo-planar DTI was acquired in 32 non-collinear directions. Tractography of the direct pathway of the superior longitudinal fasciculus (SLFd) and uncinate fasciculus of both hemispheres was performed, and ROIs at the anterior cingulum and external capsule of both hemispheres were drawn. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD) and Trace of the ROIs and reconstructed tracts were calculated. Group comparison was performed using independent sample t-test and Fisher’s exact test. Results: Compared to healthy participants, there was significant reduction of FA of the left external capsule (p = 0.001) with increase in RD and Trace (p = .004, .048 respectively). However, the right SLFd showed significant reduction of AD (p = 0.005) and the left SLFd showed significant reduction of its volume (p = 0.02). Conclusion: In patients with FES, impaired white matter connectivity was recognized in the right SLFd and left external capsule associated with reduction in the volume of the left SLFd.http://www.sciencedirect.com/science/article/pii/S0378603X15002569First episode schizophreniaDTIAxial and Radial diffusivitySuperior longitudinal fasciculusExternal capsule |
| spellingShingle | Shaimaa Abdelsattar Mohammad Hossam Moussa Sakr Sameh Mohamed Yousri Bondok Dalia Abdel Moneim Mahmoud Hanan M.E. Azzam Safeya Effat Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study The Egyptian Journal of Radiology and Nuclear Medicine First episode schizophrenia DTI Axial and Radial diffusivity Superior longitudinal fasciculus External capsule |
| title | Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study |
| title_full | Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study |
| title_fullStr | Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study |
| title_full_unstemmed | Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study |
| title_short | Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study |
| title_sort | fronto temporal connectivity in never medicated patients with first episode schizophrenia a dti study |
| topic | First episode schizophrenia DTI Axial and Radial diffusivity Superior longitudinal fasciculus External capsule |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X15002569 |
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