Small molecules targeting endocytic uptake and recycling pathways
Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundament...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1125801/full |
| _version_ | 1797741122008645632 |
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| author | Giampaolo Placidi Giampaolo Placidi Clara Mattu Gianluca Ciardelli Gianluca Ciardelli Carlo C. Campa Carlo C. Campa |
| author_facet | Giampaolo Placidi Giampaolo Placidi Clara Mattu Gianluca Ciardelli Gianluca Ciardelli Carlo C. Campa Carlo C. Campa |
| author_sort | Giampaolo Placidi |
| collection | DOAJ |
| description | Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties for in vivo administration. Here, we review most used drugs and recently discovered small molecules able to block endocytosis and endocytic recycling pathways. We characterize such pharmacological inhibitors by emphasizing their target specificity, molecular affinity, biological activity and efficacy in both in vitro and in vivo experimental models. |
| first_indexed | 2024-03-12T14:22:19Z |
| format | Article |
| id | doaj.art-5b8e7550831c42c3b25ad193e0abe6d6 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-12T14:22:19Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5b8e7550831c42c3b25ad193e0abe6d62023-08-18T15:59:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-03-011110.3389/fcell.2023.11258011125801Small molecules targeting endocytic uptake and recycling pathwaysGiampaolo Placidi0Giampaolo Placidi1Clara Mattu2Gianluca Ciardelli3Gianluca Ciardelli4Carlo C. Campa5Carlo C. Campa6Italian Institute for Genomic Medicine, Candiolo, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, ItalyChemical-Physical Processes, National Research Council (CNR-IPCF), Pisa, ItalyItalian Institute for Genomic Medicine, Candiolo, ItalyCandiolo Cancer Institute, FPO-IRCCS, Candiolo, ItalyOver the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties for in vivo administration. Here, we review most used drugs and recently discovered small molecules able to block endocytosis and endocytic recycling pathways. We characterize such pharmacological inhibitors by emphasizing their target specificity, molecular affinity, biological activity and efficacy in both in vitro and in vivo experimental models.https://www.frontiersin.org/articles/10.3389/fcell.2023.1125801/fullendocytosisendocytic recyclingsmall moleculesinhibitorsmechanism of action |
| spellingShingle | Giampaolo Placidi Giampaolo Placidi Clara Mattu Gianluca Ciardelli Gianluca Ciardelli Carlo C. Campa Carlo C. Campa Small molecules targeting endocytic uptake and recycling pathways Frontiers in Cell and Developmental Biology endocytosis endocytic recycling small molecules inhibitors mechanism of action |
| title | Small molecules targeting endocytic uptake and recycling pathways |
| title_full | Small molecules targeting endocytic uptake and recycling pathways |
| title_fullStr | Small molecules targeting endocytic uptake and recycling pathways |
| title_full_unstemmed | Small molecules targeting endocytic uptake and recycling pathways |
| title_short | Small molecules targeting endocytic uptake and recycling pathways |
| title_sort | small molecules targeting endocytic uptake and recycling pathways |
| topic | endocytosis endocytic recycling small molecules inhibitors mechanism of action |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1125801/full |
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