Epstein-Barr virus: Current questions and challenges
Epstein-Barr virus (EBV) infects most people worldwide and persists for life due to complicated interplay between lytic infection and multiple types of latent infections. While usually asymptomatic, EBV is a causative agent in several types of cancer and has a strong association with multiple sclero...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Tumour Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679021000082 |
| _version_ | 1818575258112753664 |
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| author | Lori Frappier |
| author_facet | Lori Frappier |
| author_sort | Lori Frappier |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) infects most people worldwide and persists for life due to complicated interplay between lytic infection and multiple types of latent infections. While usually asymptomatic, EBV is a causative agent in several types of cancer and has a strong association with multiple sclerosis. Exactly how EBV promotes these diseases and why they are rare consequences of infection are incompletely understood. Here I will discuss current ideas on disease induction by EBV, including the importance of lytic protein expression in the context of latent infection as well as the possible importance of specific EBV variants in disease induction. |
| first_indexed | 2024-12-15T00:37:52Z |
| format | Article |
| id | doaj.art-5b8e934d9da7454c9fbb197618b0d603 |
| institution | Directory Open Access Journal |
| issn | 2666-6790 |
| language | English |
| last_indexed | 2024-12-15T00:37:52Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj.art-5b8e934d9da7454c9fbb197618b0d6032022-12-21T22:41:44ZengElsevierTumour Virus Research2666-67902021-12-0112200218Epstein-Barr virus: Current questions and challengesLori Frappier0Department of Molecular Genetics, University of Toronto, 661 University Ave, Suite 1600, Toronto, ON, M5G 1M1, CanadaEpstein-Barr virus (EBV) infects most people worldwide and persists for life due to complicated interplay between lytic infection and multiple types of latent infections. While usually asymptomatic, EBV is a causative agent in several types of cancer and has a strong association with multiple sclerosis. Exactly how EBV promotes these diseases and why they are rare consequences of infection are incompletely understood. Here I will discuss current ideas on disease induction by EBV, including the importance of lytic protein expression in the context of latent infection as well as the possible importance of specific EBV variants in disease induction.http://www.sciencedirect.com/science/article/pii/S2666679021000082Cancer inductionAbortive lytic infectionViral variantsMultiple sclerosis |
| spellingShingle | Lori Frappier Epstein-Barr virus: Current questions and challenges Tumour Virus Research Cancer induction Abortive lytic infection Viral variants Multiple sclerosis |
| title | Epstein-Barr virus: Current questions and challenges |
| title_full | Epstein-Barr virus: Current questions and challenges |
| title_fullStr | Epstein-Barr virus: Current questions and challenges |
| title_full_unstemmed | Epstein-Barr virus: Current questions and challenges |
| title_short | Epstein-Barr virus: Current questions and challenges |
| title_sort | epstein barr virus current questions and challenges |
| topic | Cancer induction Abortive lytic infection Viral variants Multiple sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666679021000082 |
| work_keys_str_mv | AT lorifrappier epsteinbarrviruscurrentquestionsandchallenges |