Genetic causal association between physical activities and epilepsy: A Mendelian randomization study
Abstract Background Despite numerous investigations into the relationship between physical activities (PA) and epilepsy, the causal effects remain contentious. Thus, we conducted a two‐sample Mendelian randomization (MR) study to assess the potential causality. Methods Single‐nucleotide polymorphism...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3463 |
| _version_ | 1797244771853402112 |
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| author | Peihong Li Jiaxin Li Zheng Xiao Dandan Sheng Weiping Liu Bo Xiao Luo Zhou |
| author_facet | Peihong Li Jiaxin Li Zheng Xiao Dandan Sheng Weiping Liu Bo Xiao Luo Zhou |
| author_sort | Peihong Li |
| collection | DOAJ |
| description | Abstract Background Despite numerous investigations into the relationship between physical activities (PA) and epilepsy, the causal effects remain contentious. Thus, we conducted a two‐sample Mendelian randomization (MR) study to assess the potential causality. Methods Single‐nucleotide polymorphisms (SNPs) predisposed to self‐reported moderate and vigorous physical activities (MPA and VPA) and overall acceleration average (OAA) calculated through wrist‐worn accelerometers were selected as exposure instrumental variables. Five subtypes of epilepsy, including all epilepsy, focal epilepsy and generalized epilepsy (with or without each other), focal epilepsy‐strict definition and generalized epilepsy‐strict definition (without overlap), were chosen as the outcomes. The MR study utilized the inverse‐variance weighted (IVW) method as the primary analytical tool, supplemented by MR‐Egger, simple mode, weighted mode, and weighted median methods. Cochran's Q and MR‐Egger intercept tests were employed to assess heterogeneity and pleiotropy, while MR pleiotropy residual sum and outlier and leave‐one‐out analyses were conducted to identify potential SNP outliers. Results The study indicated that OAA was genetically linked to a decreased risk of both focal epilepsy (OR = 0.812, 95% CI: 0.687–0.960, p = .015, IVW) and focal epilepsy‐strict definition (OR = 0.732, 95% CI: 0.596–0.900, p = .003, IVW; OR = 0.749, 95% CI: 0.573−0.979, p = .035, Weighted median). Genetically predicted MPA and VPA did not exhibit a causal association with all epilepsy or its subtypes (p>.05). No evidence of heterogeneity, pleiotropy, or SNP outlier was observed. Conclusions Our findings suggested that PA with accelerometer monitoring may potentially reduce the risk of focal epilepsy, while there is no evidence supporting causal association between self‐reported MPA or VPA and either focal or generalized epilepsy. |
| first_indexed | 2024-04-24T19:16:19Z |
| format | Article |
| id | doaj.art-5b8ee80df8b34736aeae528b11127ec8 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-24T19:16:19Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-5b8ee80df8b34736aeae528b11127ec82024-03-26T05:06:44ZengWileyBrain and Behavior2162-32792024-03-01143n/an/a10.1002/brb3.3463Genetic causal association between physical activities and epilepsy: A Mendelian randomization studyPeihong Li0Jiaxin Li1Zheng Xiao2Dandan Sheng3Weiping Liu4Bo Xiao5Luo Zhou6Department of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Pathology First Hospital of Changsha Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan ChinaAbstract Background Despite numerous investigations into the relationship between physical activities (PA) and epilepsy, the causal effects remain contentious. Thus, we conducted a two‐sample Mendelian randomization (MR) study to assess the potential causality. Methods Single‐nucleotide polymorphisms (SNPs) predisposed to self‐reported moderate and vigorous physical activities (MPA and VPA) and overall acceleration average (OAA) calculated through wrist‐worn accelerometers were selected as exposure instrumental variables. Five subtypes of epilepsy, including all epilepsy, focal epilepsy and generalized epilepsy (with or without each other), focal epilepsy‐strict definition and generalized epilepsy‐strict definition (without overlap), were chosen as the outcomes. The MR study utilized the inverse‐variance weighted (IVW) method as the primary analytical tool, supplemented by MR‐Egger, simple mode, weighted mode, and weighted median methods. Cochran's Q and MR‐Egger intercept tests were employed to assess heterogeneity and pleiotropy, while MR pleiotropy residual sum and outlier and leave‐one‐out analyses were conducted to identify potential SNP outliers. Results The study indicated that OAA was genetically linked to a decreased risk of both focal epilepsy (OR = 0.812, 95% CI: 0.687–0.960, p = .015, IVW) and focal epilepsy‐strict definition (OR = 0.732, 95% CI: 0.596–0.900, p = .003, IVW; OR = 0.749, 95% CI: 0.573−0.979, p = .035, Weighted median). Genetically predicted MPA and VPA did not exhibit a causal association with all epilepsy or its subtypes (p>.05). No evidence of heterogeneity, pleiotropy, or SNP outlier was observed. Conclusions Our findings suggested that PA with accelerometer monitoring may potentially reduce the risk of focal epilepsy, while there is no evidence supporting causal association between self‐reported MPA or VPA and either focal or generalized epilepsy.https://doi.org/10.1002/brb3.3463epilepsyMendelian randomizationphysical activities |
| spellingShingle | Peihong Li Jiaxin Li Zheng Xiao Dandan Sheng Weiping Liu Bo Xiao Luo Zhou Genetic causal association between physical activities and epilepsy: A Mendelian randomization study Brain and Behavior epilepsy Mendelian randomization physical activities |
| title | Genetic causal association between physical activities and epilepsy: A Mendelian randomization study |
| title_full | Genetic causal association between physical activities and epilepsy: A Mendelian randomization study |
| title_fullStr | Genetic causal association between physical activities and epilepsy: A Mendelian randomization study |
| title_full_unstemmed | Genetic causal association between physical activities and epilepsy: A Mendelian randomization study |
| title_short | Genetic causal association between physical activities and epilepsy: A Mendelian randomization study |
| title_sort | genetic causal association between physical activities and epilepsy a mendelian randomization study |
| topic | epilepsy Mendelian randomization physical activities |
| url | https://doi.org/10.1002/brb3.3463 |
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