Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange
A 52-year-old man presented with behavioral and cognitive symptoms and involuntary movements. Serum CASPR-2 antibodies were strongly positive, and the nerve conduction study showed hyperexcitability. Thus, it was diagnosed as a case of Morvan's syndrome, detected after 3 months. The failed ther...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Global Journal of Transfusion Medicine |
| Subjects: | |
| Online Access: | http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2023;volume=8;issue=2;spage=202;epage=204;aulast=Kumatagi |
| _version_ | 1827270044771418112 |
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| author | Shivanand Hemant Kumatagi R Amod Sajith Sukumaran Debasish Gupta |
| author_facet | Shivanand Hemant Kumatagi R Amod Sajith Sukumaran Debasish Gupta |
| author_sort | Shivanand Hemant Kumatagi |
| collection | DOAJ |
| description | A 52-year-old man presented with behavioral and cognitive symptoms and involuntary movements. Serum CASPR-2 antibodies were strongly positive, and the nerve conduction study showed hyperexcitability. Thus, it was diagnosed as a case of Morvan's syndrome, detected after 3 months. The failed therapy with steroids led to the initiation of the therapeutic plasma exchange (TPE). Five cycles of TPE were completed to improve dramatically the cognitive and behavioral issues as well as the involuntary movements. He was initiated on rituximab for long-term maintenance therapy. In conclusion, TPE can be initiated even after 3 months of onset to achieve significant recovery. Although it is challenging, it is still a tolerated procedure with good outcomes. |
| first_indexed | 2024-03-08T13:11:15Z |
| format | Article |
| id | doaj.art-5b8fd52d739f420c9e42f68847372a81 |
| institution | Directory Open Access Journal |
| issn | 2468-8398 2455-8893 |
| language | English |
| last_indexed | 2025-03-22T05:15:10Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Global Journal of Transfusion Medicine |
| spelling | doaj.art-5b8fd52d739f420c9e42f68847372a812024-04-27T05:29:50ZengWolters Kluwer Medknow PublicationsGlobal Journal of Transfusion Medicine2468-83982455-88932023-01-018220220410.4103/gjtm.gjtm_51_23Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchangeShivanand Hemant KumatagiR AmodSajith SukumaranDebasish GuptaA 52-year-old man presented with behavioral and cognitive symptoms and involuntary movements. Serum CASPR-2 antibodies were strongly positive, and the nerve conduction study showed hyperexcitability. Thus, it was diagnosed as a case of Morvan's syndrome, detected after 3 months. The failed therapy with steroids led to the initiation of the therapeutic plasma exchange (TPE). Five cycles of TPE were completed to improve dramatically the cognitive and behavioral issues as well as the involuntary movements. He was initiated on rituximab for long-term maintenance therapy. In conclusion, TPE can be initiated even after 3 months of onset to achieve significant recovery. Although it is challenging, it is still a tolerated procedure with good outcomes.http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2023;volume=8;issue=2;spage=202;epage=204;aulast=Kumatagiapheresismorvan's syndrometherapeutic plasma exchange |
| spellingShingle | Shivanand Hemant Kumatagi R Amod Sajith Sukumaran Debasish Gupta Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange Global Journal of Transfusion Medicine apheresis morvan's syndrome therapeutic plasma exchange |
| title | Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange |
| title_full | Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange |
| title_fullStr | Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange |
| title_full_unstemmed | Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange |
| title_short | Successful management of steroid-refractory Morvan's syndrome 3 months after onset with therapeutic plasma exchange |
| title_sort | successful management of steroid refractory morvan s syndrome 3 months after onset with therapeutic plasma exchange |
| topic | apheresis morvan's syndrome therapeutic plasma exchange |
| url | http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2023;volume=8;issue=2;spage=202;epage=204;aulast=Kumatagi |
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