Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics
The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302587/full |
| _version_ | 1797265534826315776 |
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| author | Tosin Akinsipe Rania Mohamedelhassan Ayuba Akinpelu Satyanarayana R. Pondugula Panagiotis Mistriotis L. Adriana Avila Amol Suryawanshi |
| author_facet | Tosin Akinsipe Rania Mohamedelhassan Ayuba Akinpelu Satyanarayana R. Pondugula Panagiotis Mistriotis L. Adriana Avila Amol Suryawanshi |
| author_sort | Tosin Akinsipe |
| collection | DOAJ |
| description | The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conventional and newly developed anti-tumor therapies. Both immune and non-immune cells in the TME play critical roles in tumor onset, uncontrolled proliferation, metastasis, immune evasion, and resistance to anti-tumor therapies. Consequently, molecular and cellular components of breast TME have emerged as promising therapeutic targets for developing novel treatments. The breast TME primarily comprises cancer cells, stromal cells, vasculature, and infiltrating immune cells. Currently, numerous clinical trials targeting specific TME components of breast cancer are underway. However, the complexity of the TME and its impact on the evasion of anti-tumor immunity necessitate further research to develop novel and improved breast cancer therapies. The multifaceted nature of breast TME cells arises from their phenotypic and functional plasticity, which endows them with both pro and anti-tumor roles during tumor progression. In this review, we discuss current understanding and recent advances in the pro and anti-tumoral functions of TME cells and their implications for developing safe and effective therapies to control breast cancer progress. |
| first_indexed | 2024-04-25T00:46:20Z |
| format | Article |
| id | doaj.art-5b9000da7d0d456998136d96c387be86 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-25T00:46:20Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5b9000da7d0d456998136d96c387be862024-03-12T04:25:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13025871302587Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeuticsTosin Akinsipe0Rania Mohamedelhassan1Ayuba Akinpelu2Satyanarayana R. Pondugula3Panagiotis Mistriotis4L. Adriana Avila5Amol Suryawanshi6Department of Biological Sciences, College of Science and Mathematics, Auburn University, Auburn, AL, United StatesDepartment of Chemical Engineering, College of Engineering, Auburn University, Auburn, AL, United StatesDepartment of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Chemical Engineering, College of Engineering, Auburn University, Auburn, AL, United StatesDepartment of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Biological Sciences, College of Science and Mathematics, Auburn University, Auburn, AL, United StatesDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesThe breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conventional and newly developed anti-tumor therapies. Both immune and non-immune cells in the TME play critical roles in tumor onset, uncontrolled proliferation, metastasis, immune evasion, and resistance to anti-tumor therapies. Consequently, molecular and cellular components of breast TME have emerged as promising therapeutic targets for developing novel treatments. The breast TME primarily comprises cancer cells, stromal cells, vasculature, and infiltrating immune cells. Currently, numerous clinical trials targeting specific TME components of breast cancer are underway. However, the complexity of the TME and its impact on the evasion of anti-tumor immunity necessitate further research to develop novel and improved breast cancer therapies. The multifaceted nature of breast TME cells arises from their phenotypic and functional plasticity, which endows them with both pro and anti-tumor roles during tumor progression. In this review, we discuss current understanding and recent advances in the pro and anti-tumoral functions of TME cells and their implications for developing safe and effective therapies to control breast cancer progress.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302587/fulltumor microenvironmentstromaimmune cellsbreast cancermetastasis |
| spellingShingle | Tosin Akinsipe Rania Mohamedelhassan Ayuba Akinpelu Satyanarayana R. Pondugula Panagiotis Mistriotis L. Adriana Avila Amol Suryawanshi Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics Frontiers in Immunology tumor microenvironment stroma immune cells breast cancer metastasis |
| title | Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics |
| title_full | Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics |
| title_fullStr | Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics |
| title_full_unstemmed | Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics |
| title_short | Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics |
| title_sort | cellular interactions in tumor microenvironment during breast cancer progression new frontiers and implications for novel therapeutics |
| topic | tumor microenvironment stroma immune cells breast cancer metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302587/full |
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