The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong
The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on pharmacokinetics. Thirty-two rats were randomly divided into four groups: CN, healthy rats after a single administration of Chuanx...
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01461/full |
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| author | Haigang Li Haigang Li Yu Jiang Yang Wang Huiying Lv Haitang Xie Guoping Yang Chengxian Guo Jing Tang Tao Tang |
| author_facet | Haigang Li Haigang Li Yu Jiang Yang Wang Huiying Lv Haitang Xie Guoping Yang Chengxian Guo Jing Tang Tao Tang |
| author_sort | Haigang Li |
| collection | DOAJ |
| description | The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on pharmacokinetics. Thirty-two rats were randomly divided into four groups: CN, healthy rats after a single administration of Chuanxiong; CO, rats with biliary drainage after a single administration of Chuanxiong; WCN, healthy rats after the administration of Chuanxiong and warfarin; WCO, rats with biliary drainage after the administration of Chuanxiong and warfarin. A series of blood samples were collected at different time points before and after oral administration. An ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for quantification of the main components of Chuanxiong and methyclothiazide (internal standard) have been established. The validated method was successfully applied to a comparative pharmacokinetics study. After calculated by the DAS 2.1.1 software, the pharmacokinetics parameters of senkyunolide I showed a significant difference between the CN and CO groups, the AUC0−t, and Cmax of CO group increased by 5.45, 4.02 folds, respectively. There was a significant difference between the WCO and WCN groups, the Tmax of WCO group prolonged 67%; compared to the CN group, the AUC0−t, and Cmax of WCN group raised 4.84, 3.49 folds, respectively; the Tmax and Cmax between the CO and WCO groups also showed a significant difference. The drug warfarin significantly affected the senkyunolide I disposition, which partly due to its enterohepatic circulation process in rat plasma after oral administration of Chuanxiong. The present study highlights an urgent evidence for drug-herb interactions. |
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| last_indexed | 2024-12-21T15:31:21Z |
| publishDate | 2018-12-01 |
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| spelling | doaj.art-5b94c73e961b487b9aab8097ee20d1ae2022-12-21T18:58:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-12-01910.3389/fphar.2018.01461373968The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of ChuanxiongHaigang Li0Haigang Li1Yu Jiang2Yang Wang3Huiying Lv4Haitang Xie5Guoping Yang6Chengxian Guo7Jing Tang8Tao Tang9Department of Pharmacy, Changsha Medical University, Changsha, ChinaInstitute of Integrative Chinese Medicine, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Gerontology, Affiliated Hospital of T.C.M. of Xinjiang Medical University, Urumqi, ChinaInstitute of Integrative Chinese Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Agricultural Product Processing Institute, Hunan Academy of Agricultural Sciences, Changsha, ChinaAnhui Provincial Centre for Drug Clinical Evaluation, The First Affiliated Hospital of Wannan Medical College, Wuhu, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pharmacy, Changsha Medical University, Changsha, ChinaInstitute of Integrative Chinese Medicine, Xiangya Hospital, Central South University, Changsha, ChinaThe aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on pharmacokinetics. Thirty-two rats were randomly divided into four groups: CN, healthy rats after a single administration of Chuanxiong; CO, rats with biliary drainage after a single administration of Chuanxiong; WCN, healthy rats after the administration of Chuanxiong and warfarin; WCO, rats with biliary drainage after the administration of Chuanxiong and warfarin. A series of blood samples were collected at different time points before and after oral administration. An ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for quantification of the main components of Chuanxiong and methyclothiazide (internal standard) have been established. The validated method was successfully applied to a comparative pharmacokinetics study. After calculated by the DAS 2.1.1 software, the pharmacokinetics parameters of senkyunolide I showed a significant difference between the CN and CO groups, the AUC0−t, and Cmax of CO group increased by 5.45, 4.02 folds, respectively. There was a significant difference between the WCO and WCN groups, the Tmax of WCO group prolonged 67%; compared to the CN group, the AUC0−t, and Cmax of WCN group raised 4.84, 3.49 folds, respectively; the Tmax and Cmax between the CO and WCO groups also showed a significant difference. The drug warfarin significantly affected the senkyunolide I disposition, which partly due to its enterohepatic circulation process in rat plasma after oral administration of Chuanxiong. The present study highlights an urgent evidence for drug-herb interactions.https://www.frontiersin.org/article/10.3389/fphar.2018.01461/fullsenkyunolide IChuanxiongwarfarinpharmacokineticsUPLC-MS/MSbiliary drainage |
| spellingShingle | Haigang Li Haigang Li Yu Jiang Yang Wang Huiying Lv Haitang Xie Guoping Yang Chengxian Guo Jing Tang Tao Tang The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong Frontiers in Pharmacology senkyunolide I Chuanxiong warfarin pharmacokinetics UPLC-MS/MS biliary drainage |
| title | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong |
| title_full | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong |
| title_fullStr | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong |
| title_full_unstemmed | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong |
| title_short | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong |
| title_sort | effects of warfarin on the pharmacokinetics of senkyunolide i in a rat model of biliary drainage after administration of chuanxiong |
| topic | senkyunolide I Chuanxiong warfarin pharmacokinetics UPLC-MS/MS biliary drainage |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01461/full |
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