Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy
Pharmacomodulation of membrane channels is an essential topic in the study of physiological conditions and disease status. Transient receptor potential (TRP) channels are one such family of nonselective cation channels that have an important influence. In mammals, TRP channels consist of seven subfa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4714 |
| _version_ | 1797615159138582528 |
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| author | Felix Yang Andy Sivils Victoria Cegielski Som Singh Xiang-Ping Chu |
| author_facet | Felix Yang Andy Sivils Victoria Cegielski Som Singh Xiang-Ping Chu |
| author_sort | Felix Yang |
| collection | DOAJ |
| description | Pharmacomodulation of membrane channels is an essential topic in the study of physiological conditions and disease status. Transient receptor potential (TRP) channels are one such family of nonselective cation channels that have an important influence. In mammals, TRP channels consist of seven subfamilies with a total of twenty-eight members. Evidence shows that TRP channels mediate cation transduction in neuronal signaling, but the full implication and potential therapeutic applications of this are not entirely clear. In this review, we aim to highlight several TRP channels which have been shown to mediate pain sensation, neuropsychiatric disorders, and epilepsy. Recent findings suggest that TRPM (melastatin), TRPV (vanilloid), and TRPC (canonical) are of particular relevance to these phenomena. The research reviewed in this paper validates these TRP channels as potential targets of future clinical treatment and offers patients hope for more effective care. |
| first_indexed | 2024-03-11T07:22:32Z |
| format | Article |
| id | doaj.art-5b968e90002c48159fb7be87aa5f6b7d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:32Z |
| publishDate | 2023-03-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5b968e90002c48159fb7be87aa5f6b7d2023-11-17T07:52:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245471410.3390/ijms24054714Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and EpilepsyFelix Yang0Andy Sivils1Victoria Cegielski2Som Singh3Xiang-Ping Chu4Department of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USAPharmacomodulation of membrane channels is an essential topic in the study of physiological conditions and disease status. Transient receptor potential (TRP) channels are one such family of nonselective cation channels that have an important influence. In mammals, TRP channels consist of seven subfamilies with a total of twenty-eight members. Evidence shows that TRP channels mediate cation transduction in neuronal signaling, but the full implication and potential therapeutic applications of this are not entirely clear. In this review, we aim to highlight several TRP channels which have been shown to mediate pain sensation, neuropsychiatric disorders, and epilepsy. Recent findings suggest that TRPM (melastatin), TRPV (vanilloid), and TRPC (canonical) are of particular relevance to these phenomena. The research reviewed in this paper validates these TRP channels as potential targets of future clinical treatment and offers patients hope for more effective care.https://www.mdpi.com/1422-0067/24/5/4714transient receptor potential channelsTRPTRPMTRPVTRPCpain |
| spellingShingle | Felix Yang Andy Sivils Victoria Cegielski Som Singh Xiang-Ping Chu Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy International Journal of Molecular Sciences transient receptor potential channels TRP TRPM TRPV TRPC pain |
| title | Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy |
| title_full | Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy |
| title_fullStr | Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy |
| title_full_unstemmed | Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy |
| title_short | Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy |
| title_sort | transient receptor potential trp channels in pain neuropsychiatric disorders and epilepsy |
| topic | transient receptor potential channels TRP TRPM TRPV TRPC pain |
| url | https://www.mdpi.com/1422-0067/24/5/4714 |
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