Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents
Furopyrimidines are fused heterocyclic ring systems. Structurally, they are bioisoteres to purines and exerting pharmacological actions in various aspects. They are known to play an important role in different disease conditions. Furo[2,3-d]pyrimidines derivatives have been explored for their inhibi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016-06-01
|
| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314724515300327 |
| _version_ | 1818924084047642624 |
|---|---|
| author | Marwa A. Aziz Rabah A.T. Serya Deena S. Lasheen Khaled A.M. Abouzid |
| author_facet | Marwa A. Aziz Rabah A.T. Serya Deena S. Lasheen Khaled A.M. Abouzid |
| author_sort | Marwa A. Aziz |
| collection | DOAJ |
| description | Furopyrimidines are fused heterocyclic ring systems. Structurally, they are bioisoteres to purines and exerting pharmacological actions in various aspects. They are known to play an important role in different disease conditions. Furo[2,3-d]pyrimidines derivatives have been explored for their inhibitory activity against different protein kinase enzymes. The present review, to the best of our knowledge, is the first compilation on synthesis, anticancer activity, via inhibition of various protein kinase enzymes, and structure–activity relationships of furo[2,3-d]pyrimidines derivatives reported to date. |
| first_indexed | 2024-12-20T02:19:42Z |
| format | Article |
| id | doaj.art-5b9802a4b24540d9b25615888eb86b2f |
| institution | Directory Open Access Journal |
| issn | 2314-7245 |
| language | English |
| last_indexed | 2024-12-20T02:19:42Z |
| publishDate | 2016-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-5b9802a4b24540d9b25615888eb86b2f2022-12-21T19:56:50ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72452016-06-01211810.1016/j.fjps.2015.12.001Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agentsMarwa A. AzizRabah A.T. SeryaDeena S. LasheenKhaled A.M. AbouzidFuropyrimidines are fused heterocyclic ring systems. Structurally, they are bioisoteres to purines and exerting pharmacological actions in various aspects. They are known to play an important role in different disease conditions. Furo[2,3-d]pyrimidines derivatives have been explored for their inhibitory activity against different protein kinase enzymes. The present review, to the best of our knowledge, is the first compilation on synthesis, anticancer activity, via inhibition of various protein kinase enzymes, and structure–activity relationships of furo[2,3-d]pyrimidines derivatives reported to date.http://www.sciencedirect.com/science/article/pii/S2314724515300327Kinase inhibitorsFuro[2,3-d]pyrimidineSynthetic strategyAnticancer |
| spellingShingle | Marwa A. Aziz Rabah A.T. Serya Deena S. Lasheen Khaled A.M. Abouzid Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents Future Journal of Pharmaceutical Sciences Kinase inhibitors Furo[2,3-d]pyrimidine Synthetic strategy Anticancer |
| title | Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_full | Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_fullStr | Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_full_unstemmed | Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_short | Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_sort | furo 2 3 d pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| topic | Kinase inhibitors Furo[2,3-d]pyrimidine Synthetic strategy Anticancer |
| url | http://www.sciencedirect.com/science/article/pii/S2314724515300327 |
| work_keys_str_mv | AT marwaaaziz furo23dpyrimidinebasedderivativesaskinaseinhibitorsandanticanceragents AT rabahatserya furo23dpyrimidinebasedderivativesaskinaseinhibitorsandanticanceragents AT deenaslasheen furo23dpyrimidinebasedderivativesaskinaseinhibitorsandanticanceragents AT khaledamabouzid furo23dpyrimidinebasedderivativesaskinaseinhibitorsandanticanceragents |