Human corneal stromal stem cells express anti-fibrotic microRNA-29a and 381-5p – A robust cell selection tool for stem cell therapy of corneal scarring

Human corneal stromal stem cells express anti-fibrotic microRNA-29a and 381-5p – A robust cell selection tool for stem cell therapy of corneal scarring

Introduction: Corneal blindness due to scarring is treated with corneal transplantation. However, a global problem is the donor material shortage. Preclinical and clinical studies have shown that cell-based therapy using corneal stromal stem cells (CSSCs) suppresses corneal scarring, potentially med...

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Bibliographic Details
Main Authors: Gary Hin-Fai Yam, Tianbing Yang, Moira L Geary, Mithun Santra, Martha Funderburgh, Elizabeth Rubin, Yiqin Du, Jose A Sahel, Vishal Jhanji, James L Funderburgh
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Advanced Research
Subjects:
Corneal blindness
Scarring
Stromal cell therapy
Stem cells
Extracellular vesicles
miR-29a
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222001205

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