Mediation of the APOE Associations With Cognition Through Cerebral Blood Flow: The CIBL Study

Mediation of the APOE Associations With Cognition Through Cerebral Blood Flow: The CIBL Study

BackgroundThe ε4 allele of the apolipoprotein E (APOE) gene is a strong genetic risk factor for aging-related cognitive decline. However, the causal connection between ε4 alleles and cognition is not well understood. The objective of this study was to identify the roles of cerebral blood flow (CBF)...

Full description

Bibliographic Details
Main Authors:	Yan-Li Wang, Mengfan Sun, Fang-Ze Wang, Xiaohong Wang, Ziyan Jia, Yuan Zhang, Runzhi Li, Jiwei Jiang, Linlin Wang, Wenyi Li, Yongan Sun, Jinglong Chen, Cuicui Zhang, Baolin Shi, Jianjian Liu, Xiangrong Liu, Jun Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Aging Neuroscience
Subjects:	APOE ε4 cerebral blood flow cognition causal mediation CIBL study
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.928925/full

Similar Items

Association of APOE Serum Levels and <i>APOE</i> ε2, ε3, and ε4 Alleles with Optic Neuritis
by: Liucija Momkute, et al.
Published: (2022-07-01)

APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3
by: Alireza Nazarian, et al.
Published: (2022-10-01)

Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly
by: Zhiyuan Wang, et al.
Published: (2023-08-01)

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort
by: Li Shang, et al.
Published: (2023-03-01)

Corrigendum: Differences in resting-state brain networks and gray matter between APOE ϵ2 and APOE ϵ4 carriers in non-dementia elderly
by: Zhiyuan Wang, et al.
Published: (2024-01-01)

Quelle prise en compte du genre dans la communication publique ?
by: Sandrine Roginsky
Published: (2021-05-01)

Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program
by: Valery Gafarov, et al.
Published: (2023-08-01)

APOE ε4 Allele Distribution and Association With Scores of Subjective Cognitive Decline Questionnaire 9 in a Large Chinese Memory Clinic Cohort
by: Lixiao Hao, et al.
Published: (2022-06-01)

Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study
by: Panpan He, et al.
Published: (2023-01-01)

APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses
by: Sarah Bonk, et al.
Published: (2022-06-01)

Association between PSEN1 p.E318G Variant and APOE Polymorphism and Alzheimer Disease in Turkish Patients
by: Gamze Güven, et al.
Published: (2021-06-01)

Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes
by: Rebecca Piccarducci, et al.
Published: (2019-11-01)

Corrigendum: The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging
by: Dongpeng Wu, et al.
Published: (2022-05-01)

Potential role of APOE ɛ4 allele as a modifier for the association of BDNF Val66Met polymorphisms and cognitive impairment in community-dwelling older adults
by: Shaozhen Ji, et al.
Published: (2024-02-01)

APOE ε4 allele status modulates the spatial patterns of progressive atrophy in the temporal lobes after mild traumatic brain injury
by: Shuoqiu Gan, et al.
Published: (2024-01-01)

APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
by: Anna Brugulat-Serrat, et al.
Published: (2023-03-01)

A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation
by: Yuhao Liu, et al.
Published: (2024-03-01)

Les Culturèmes : Les Difficultés De La Traduction Des Unités Culturelles : Étude Sur Les Œuvres De Hrant Matévosyan
by: Gayané Sargsyan
Published: (2023-04-01)

Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity
by: Badri Vardarajan, et al.
Published: (2020-01-01)

Day‐to‐day sleep variability with Alzheimer's biomarkers in at‐risk elderly
by: Andrée‐Ann Baril, et al.
Published: (2024-01-01)

The Role of APOE and NF-κB in Alzheimer’s Disease
by: Don A. Davies
Published: (2021-10-01)

ApoE transiently regulates hippocampus amyloid‐beta deposition to stable learning and memory ability in adult rats exposed in sevoflurane
by: Shan Xu, et al.
Published: (2021-06-01)

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
by: Seth Talyansky, et al.
Published: (2023-09-01)

Modulation of associations between education years and cortical volume in Alzheimer’s disease vulnerable brain regions by Aβ deposition and APOE ε4 carrier status in cognitively normal older adults
by: Hak-Bin Kim, et al.
Published: (2023-09-01)

The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
by: Chelsie N. Berg, et al.
Published: (2019-11-01)

Les limites de la traduction automatique de la métaphore dans le discours politique d’Emmanuel Macron (Français / Arabe)
by: Marwa AMMARI
Published: (2023-12-01)

LES REPRÉSENTATIONS SOCIOCULTURELLES À TRAVERS LES SUPPORTS DU MANUEL SCOLAIRE DE LA QUATRIÈME ANNÉE PRIMAIRE
by: Khadidja Elbachir
Published: (2023-12-01)

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk
by: Kenneth Maiese
Published: (2023-11-01)

Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy
by: Anna Bonaterra-Pastra, et al.
Published: (2023-04-01)

An APOS Analysis of students’ understanding of the concept of a limit of a function
by: Aneshkumar Maharaj
Published: (2010-07-01)

<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
by: Stephanie Lozano, et al.
Published: (2021-11-01)

Revisiting an old relationship: the causal associations of the ApoB/ApoA1 ratio with cardiometabolic diseases and relative risk factors—a mendelian randomization analysis
by: Chao Fu, et al.
Published: (2024-02-01)

Ghrelin improves endothelial function and plaque stability after myocardial infarction in ApoE-/- mice
by: WANG Li, PANG Jun, CHEN Qing-wei, LI Gui-qiong, KE Da-zhi, LI Xing-sheng
Published: (2021-07-01)

Agir professoral et démarche intégrée autour des formes pronominales contrastées du verbe en arabe/français
by: Noureddine Bahloul
Published: (2017-12-01)

Impact of Transcranial Direct Current Stimulation on Cognitive Function, Brain Functional Segregation, and Integration in Patients with Mild Cognitive Impairment According to Amyloid-Beta Deposition and <i>APOE</i> ε4-Allele: A Pilot Study
by: Dong-Woo Kang, et al.
Published: (2021-06-01)

ApoB100 and Atherosclerosis: What’s New in the 21st Century?
by: Dimitris Kounatidis, et al.
Published: (2024-02-01)

APOE expression and secretion are modulated by mitochondrial dysfunction
by: Meghan E Wynne, et al.
Published: (2023-05-01)

Cognitive Impairment in Multiple Sclerosis
by: Kenneth Maiese
Published: (2023-07-01)

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease
by: Andreas Giannisis, et al.
Published: (2022-08-01)

ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke
by: Li Li, et al.
Published: (2020-06-01)