Case Report of an Injectional Anthrax in France, 2012
(1) Background: <i>Bacillus anthracis</i> is a spore-forming, Gram-positive bacterium causing anthrax, a zoonosis affecting mainly livestock. When occasionally infecting humans, <i>B. anthracis</i> provokes three different clinical forms: cutaneous, digestive and inhalational...
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MDPI AG
2020-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/7/985 |
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| author | Jean-Marc Thouret Olivier Rogeaux Emmanuel Beaudouin Marion Levast Vincent Ramisse Fabrice V. Biot Eric Valade François Thibault Olivier Gorgé Jean-Nicolas Tournier |
| author_facet | Jean-Marc Thouret Olivier Rogeaux Emmanuel Beaudouin Marion Levast Vincent Ramisse Fabrice V. Biot Eric Valade François Thibault Olivier Gorgé Jean-Nicolas Tournier |
| author_sort | Jean-Marc Thouret |
| collection | DOAJ |
| description | (1) Background: <i>Bacillus anthracis</i> is a spore-forming, Gram-positive bacterium causing anthrax, a zoonosis affecting mainly livestock. When occasionally infecting humans, <i>B. anthracis</i> provokes three different clinical forms: cutaneous, digestive and inhalational anthrax. More recently, an injectional anthrax form has been described in intravenous drug users. (2) Case presentation: We report here the clinical and microbiological features, as well as the strain phylogenetic analysis, of the only injectional anthrax case observed in France so far. A 27-year-old patient presented a massive dermohypodermatitis with an extensive edema of the right arm, and the development of drug-resistant shocks. After three weeks in an intensive care unit, the patient recovered, but the microbiological identification of <i>B. anthracis</i> was achieved after a long delay. (3) Conclusions: Anthrax diagnostic may be difficult clinically and microbiologically. The phylogenetic analysis of the <i>Bacillus anthracis</i> strain PF1 confirmed its relatedness to the injectional anthrax European outbreak group-II. |
| first_indexed | 2024-03-10T18:46:23Z |
| format | Article |
| id | doaj.art-5b9c4e4eba9a429aaeefadc4fdb688d7 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:46:23Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5b9c4e4eba9a429aaeefadc4fdb688d72023-11-20T05:29:27ZengMDPI AGMicroorganisms2076-26072020-06-018798510.3390/microorganisms8070985Case Report of an Injectional Anthrax in France, 2012Jean-Marc Thouret0Olivier Rogeaux1Emmanuel Beaudouin2Marion Levast3Vincent Ramisse4Fabrice V. Biot5Eric Valade6François Thibault7Olivier Gorgé8Jean-Nicolas Tournier9Centre Hospitalier Centre Hospitalier Métropole Savoie, rue Lucien Bizet, 73000 Chambéry, FranceCentre Hospitalier Centre Hospitalier Métropole Savoie, rue Lucien Bizet, 73000 Chambéry, FranceCentre Hospitalier Centre Hospitalier Métropole Savoie, rue Lucien Bizet, 73000 Chambéry, FranceCentre Hospitalier Centre Hospitalier Métropole Savoie, rue Lucien Bizet, 73000 Chambéry, FranceDGA Maîtrise NRBC, 5 rue Lavoisier, 91710 Vert le Petit, FranceCNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, FranceCNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, FranceCNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, FranceCNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, FranceCNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, France(1) Background: <i>Bacillus anthracis</i> is a spore-forming, Gram-positive bacterium causing anthrax, a zoonosis affecting mainly livestock. When occasionally infecting humans, <i>B. anthracis</i> provokes three different clinical forms: cutaneous, digestive and inhalational anthrax. More recently, an injectional anthrax form has been described in intravenous drug users. (2) Case presentation: We report here the clinical and microbiological features, as well as the strain phylogenetic analysis, of the only injectional anthrax case observed in France so far. A 27-year-old patient presented a massive dermohypodermatitis with an extensive edema of the right arm, and the development of drug-resistant shocks. After three weeks in an intensive care unit, the patient recovered, but the microbiological identification of <i>B. anthracis</i> was achieved after a long delay. (3) Conclusions: Anthrax diagnostic may be difficult clinically and microbiologically. The phylogenetic analysis of the <i>Bacillus anthracis</i> strain PF1 confirmed its relatedness to the injectional anthrax European outbreak group-II.https://www.mdpi.com/2076-2607/8/7/985injectional anthraxdrug-useroutbreakphylogeny |
| spellingShingle | Jean-Marc Thouret Olivier Rogeaux Emmanuel Beaudouin Marion Levast Vincent Ramisse Fabrice V. Biot Eric Valade François Thibault Olivier Gorgé Jean-Nicolas Tournier Case Report of an Injectional Anthrax in France, 2012 Microorganisms injectional anthrax drug-user outbreak phylogeny |
| title | Case Report of an Injectional Anthrax in France, 2012 |
| title_full | Case Report of an Injectional Anthrax in France, 2012 |
| title_fullStr | Case Report of an Injectional Anthrax in France, 2012 |
| title_full_unstemmed | Case Report of an Injectional Anthrax in France, 2012 |
| title_short | Case Report of an Injectional Anthrax in France, 2012 |
| title_sort | case report of an injectional anthrax in france 2012 |
| topic | injectional anthrax drug-user outbreak phylogeny |
| url | https://www.mdpi.com/2076-2607/8/7/985 |
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