The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma
ObjectiveThe aim of this study was to evaluate the prognostic value for survival of parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in patients with nasopharyngeal carcinoma (NPC).MaterialsBaseline IVIM-DWI was performed on 97 newly diagnosed NPC patients i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.902819/full |
| _version_ | 1811320365687767040 |
|---|---|
| author | Yuhui Qin Chen Chen Haotian Chen Fabao Gao |
| author_facet | Yuhui Qin Chen Chen Haotian Chen Fabao Gao |
| author_sort | Yuhui Qin |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to evaluate the prognostic value for survival of parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in patients with nasopharyngeal carcinoma (NPC).MaterialsBaseline IVIM-DWI was performed on 97 newly diagnosed NPC patients in this prospective study. The relationships between the pretreatment IVIM-DWI parametric values (apparent diffusion coefficient (ADC), D, D*, and f) of the primary tumors and the patients’ 3-year survival were analyzed in 97 NPC patients who received chemoradiotherapy. The cutoff values of IVIM parameters for local relapse-free survival (LRFS) were identified by a non-parametric log-rank test. The local-regional relapse-free survival (LRRFS), LRFS, regional relapse-free survival (RRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) rates were calculated by using the Kaplan–Meier method. A Cox proportional hazards model was used to explore the independent predictors for prognosis.ResultsThere were 97 participants (mean age, 48.4 ± 10.5 years; 65 men) analyzed. Non-parametric log-rank test results showed that the optimal cutoff values of ADC, D, D*, and f were 0.897 × 10−3 mm2/s, 0.699 × 10−3 mm2/s, 8.71 × 10−3 mm2/s, and 0.198%, respectively. According to the univariable analysis, the higher ADC group demonstrated significantly higher OS rates than the low ADC group (p = 0.036), the higher D group showed significantly higher LRFS and OS rates than the low D group (p = 0.028 and p = 0.017, respectively), and the higher D* group exhibited significantly higher LRFS and OS rates than the lower D* group (p = 0.001 and p = 0.002, respectively). Multivariable analyses indicated that ADC and D were the independent prognostic factors for LRFS (p = 0.041 and p = 0.037, respectively), D was an independent prognostic factor for LRRFS (p = 0.045), D* and f were the independent prognostic factors for OS (p = 0.019 and 0.029, respectively), and f acted was an independent prognostic factor for DMFS (p = 0.020).ConclusionsBaseline IVIM-DWI perfusion parameters ADC and D, together with diffusion parameter D*, could act as useful factors for predicting long-term outcomes and selecting high-risk patients with NPC. |
| first_indexed | 2024-04-13T12:58:30Z |
| format | Article |
| id | doaj.art-5b9eb7a040d44acfb2d893c48295d05d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T12:58:30Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5b9eb7a040d44acfb2d893c48295d05d2022-12-22T02:45:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.902819902819The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinomaYuhui QinChen ChenHaotian ChenFabao GaoObjectiveThe aim of this study was to evaluate the prognostic value for survival of parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in patients with nasopharyngeal carcinoma (NPC).MaterialsBaseline IVIM-DWI was performed on 97 newly diagnosed NPC patients in this prospective study. The relationships between the pretreatment IVIM-DWI parametric values (apparent diffusion coefficient (ADC), D, D*, and f) of the primary tumors and the patients’ 3-year survival were analyzed in 97 NPC patients who received chemoradiotherapy. The cutoff values of IVIM parameters for local relapse-free survival (LRFS) were identified by a non-parametric log-rank test. The local-regional relapse-free survival (LRRFS), LRFS, regional relapse-free survival (RRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) rates were calculated by using the Kaplan–Meier method. A Cox proportional hazards model was used to explore the independent predictors for prognosis.ResultsThere were 97 participants (mean age, 48.4 ± 10.5 years; 65 men) analyzed. Non-parametric log-rank test results showed that the optimal cutoff values of ADC, D, D*, and f were 0.897 × 10−3 mm2/s, 0.699 × 10−3 mm2/s, 8.71 × 10−3 mm2/s, and 0.198%, respectively. According to the univariable analysis, the higher ADC group demonstrated significantly higher OS rates than the low ADC group (p = 0.036), the higher D group showed significantly higher LRFS and OS rates than the low D group (p = 0.028 and p = 0.017, respectively), and the higher D* group exhibited significantly higher LRFS and OS rates than the lower D* group (p = 0.001 and p = 0.002, respectively). Multivariable analyses indicated that ADC and D were the independent prognostic factors for LRFS (p = 0.041 and p = 0.037, respectively), D was an independent prognostic factor for LRRFS (p = 0.045), D* and f were the independent prognostic factors for OS (p = 0.019 and 0.029, respectively), and f acted was an independent prognostic factor for DMFS (p = 0.020).ConclusionsBaseline IVIM-DWI perfusion parameters ADC and D, together with diffusion parameter D*, could act as useful factors for predicting long-term outcomes and selecting high-risk patients with NPC.https://www.frontiersin.org/articles/10.3389/fonc.2022.902819/fullnasopharyngeal carcinomachemoradiotherapyprognosisintravoxel incoherent motiondiffusion-weighted imaginglong-term outcome |
| spellingShingle | Yuhui Qin Chen Chen Haotian Chen Fabao Gao The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma Frontiers in Oncology nasopharyngeal carcinoma chemoradiotherapy prognosis intravoxel incoherent motion diffusion-weighted imaging long-term outcome |
| title | The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma |
| title_full | The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma |
| title_fullStr | The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma |
| title_full_unstemmed | The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma |
| title_short | The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma |
| title_sort | value of intravoxel incoherent motion model based diffusion weighted imaging for predicting long term outcomes in nasopharyngeal carcinoma |
| topic | nasopharyngeal carcinoma chemoradiotherapy prognosis intravoxel incoherent motion diffusion-weighted imaging long-term outcome |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.902819/full |
| work_keys_str_mv | AT yuhuiqin thevalueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT chenchen thevalueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT haotianchen thevalueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT fabaogao thevalueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT yuhuiqin valueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT chenchen valueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT haotianchen valueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma AT fabaogao valueofintravoxelincoherentmotionmodelbaseddiffusionweightedimagingforpredictinglongtermoutcomesinnasopharyngealcarcinoma |