Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank
Background: Residential greenness has been linked to respiratory mortality, but its long-term effect on incident chronic obstructive pulmonary disease (COPD) has rarely been investigated. Methods: This prospective cohort study was based on over 350 000 participants aged 38–70 of the UK Biobank, foll...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022005815 |
| _version_ | 1828059333722636288 |
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| author | Kexin Yu Qingli Zhang Xia Meng Lina Zhang Haidong Kan Renjie Chen |
| author_facet | Kexin Yu Qingli Zhang Xia Meng Lina Zhang Haidong Kan Renjie Chen |
| author_sort | Kexin Yu |
| collection | DOAJ |
| description | Background: Residential greenness has been linked to respiratory mortality, but its long-term effect on incident chronic obstructive pulmonary disease (COPD) has rarely been investigated. Methods: This prospective cohort study was based on over 350 000 participants aged 38–70 of the UK Biobank, followed from 2006 to 2010 baseline to 2021. COPD cases were ascertained through linkages to health administrative datasets. Residential greenness was measured by satellite-derived normalized difference vegetation index (NDVI) within the 500- and 1 000-m buffer. Effects of greenness on COPD incidence were assessed using Cox proportional hazards models. We also explored mediation by physical activity, particular matter <2.5 μm in aerodynamic diameter (PM2.5) and nitrogen oxides (NOx). Restricted cubic spline models were fit to assess exposure–response relationships. Results: A total of 363 212 individuals (mean [SD] age, 56.2 [8.1] years; 193 181 [53.2 %] women] were included in the analyses. 8 261 COPD cases occurred over 4 287 926 person-years of follow-up. We observed 8% lower COPD risk per IQR increase in NDVI in the 500-m buffer (95% CI: 0.89, 0.95). The association between greenness in the 500-m buffer and COPD were partially mediated by physical activity (1.0%, 95% CI: 0.2%, 1.8%), PM2.5 (21.0%, 95% CI: 3.7%, 38.4%) and NOx (17.0%, 95% CI: 2.8%, 31.2%). Similar results were observed for NDVI within 1 000-m buffer. Conclusions: Long-term exposure to residential greenness was associated with lower risk of COPD incidence among UK adults. Our findings provide a rationale for greening policies as part of respiratory health promotion efforts. |
| first_indexed | 2024-04-10T21:41:20Z |
| format | Article |
| id | doaj.art-5b9edbd2eb914be2907debcf1ab08490 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-10T21:41:20Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-5b9edbd2eb914be2907debcf1ab084902023-01-19T04:16:05ZengElsevierEnvironment International0160-41202023-01-01171107654Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK BiobankKexin Yu0Qingli Zhang1Xia Meng2Lina Zhang3Haidong Kan4Renjie Chen5School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China; Corresponding authors.School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Corresponding authors.Background: Residential greenness has been linked to respiratory mortality, but its long-term effect on incident chronic obstructive pulmonary disease (COPD) has rarely been investigated. Methods: This prospective cohort study was based on over 350 000 participants aged 38–70 of the UK Biobank, followed from 2006 to 2010 baseline to 2021. COPD cases were ascertained through linkages to health administrative datasets. Residential greenness was measured by satellite-derived normalized difference vegetation index (NDVI) within the 500- and 1 000-m buffer. Effects of greenness on COPD incidence were assessed using Cox proportional hazards models. We also explored mediation by physical activity, particular matter <2.5 μm in aerodynamic diameter (PM2.5) and nitrogen oxides (NOx). Restricted cubic spline models were fit to assess exposure–response relationships. Results: A total of 363 212 individuals (mean [SD] age, 56.2 [8.1] years; 193 181 [53.2 %] women] were included in the analyses. 8 261 COPD cases occurred over 4 287 926 person-years of follow-up. We observed 8% lower COPD risk per IQR increase in NDVI in the 500-m buffer (95% CI: 0.89, 0.95). The association between greenness in the 500-m buffer and COPD were partially mediated by physical activity (1.0%, 95% CI: 0.2%, 1.8%), PM2.5 (21.0%, 95% CI: 3.7%, 38.4%) and NOx (17.0%, 95% CI: 2.8%, 31.2%). Similar results were observed for NDVI within 1 000-m buffer. Conclusions: Long-term exposure to residential greenness was associated with lower risk of COPD incidence among UK adults. Our findings provide a rationale for greening policies as part of respiratory health promotion efforts.http://www.sciencedirect.com/science/article/pii/S0160412022005815Chronic obstructive pulmonary diseaseGreennessProspective cohort study |
| spellingShingle | Kexin Yu Qingli Zhang Xia Meng Lina Zhang Haidong Kan Renjie Chen Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank Environment International Chronic obstructive pulmonary disease Greenness Prospective cohort study |
| title | Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank |
| title_full | Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank |
| title_fullStr | Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank |
| title_full_unstemmed | Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank |
| title_short | Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank |
| title_sort | association of residential greenness with incident chronic obstructive pulmonary disease a prospective cohort study in the uk biobank |
| topic | Chronic obstructive pulmonary disease Greenness Prospective cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022005815 |
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