Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases
Staphylococcus aureus is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains followi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-2607/6/1/25 |
| _version_ | 1819062868354531328 |
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| author | Pietro Speziale Simonetta Rindi Giampiero Pietrocola |
| author_facet | Pietro Speziale Simonetta Rindi Giampiero Pietrocola |
| author_sort | Pietro Speziale |
| collection | DOAJ |
| description | Staphylococcus aureus is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains following decades of antibiotic usage. This has generated renewed interest within the scientific community in alternative therapeutic agents, such as anti-S. aureus antibodies. Although the role of antibodies in the management of S. aureus diseases is controversial, the success of this pathogen in neutralizing humoral immunity clearly indicates that antibodies offer the host extensive protection. In this review, we report an update on efforts to develop antibody-based agents, particularly monoclonal antibodies, and their therapeutic potential in the passive immunization approach to the treatment and prevention of S. aureus infections. |
| first_indexed | 2024-12-21T15:05:37Z |
| format | Article |
| id | doaj.art-5b9f4263ca154b98ab847e840160bfc4 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-21T15:05:37Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5b9f4263ca154b98ab847e840160bfc42022-12-21T18:59:26ZengMDPI AGMicroorganisms2076-26072018-03-01612510.3390/microorganisms6010025microorganisms6010025Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus DiseasesPietro Speziale0Simonetta Rindi1Giampiero Pietrocola2Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyStaphylococcus aureus is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains following decades of antibiotic usage. This has generated renewed interest within the scientific community in alternative therapeutic agents, such as anti-S. aureus antibodies. Although the role of antibodies in the management of S. aureus diseases is controversial, the success of this pathogen in neutralizing humoral immunity clearly indicates that antibodies offer the host extensive protection. In this review, we report an update on efforts to develop antibody-based agents, particularly monoclonal antibodies, and their therapeutic potential in the passive immunization approach to the treatment and prevention of S. aureus infections.http://www.mdpi.com/2076-2607/6/1/25Staphylococcus aureusvirulence factorsantibodiespassive immunization |
| spellingShingle | Pietro Speziale Simonetta Rindi Giampiero Pietrocola Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases Microorganisms Staphylococcus aureus virulence factors antibodies passive immunization |
| title | Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases |
| title_full | Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases |
| title_fullStr | Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases |
| title_full_unstemmed | Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases |
| title_short | Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases |
| title_sort | antibody based agents in the management of antibiotic resistant staphylococcus aureus diseases |
| topic | Staphylococcus aureus virulence factors antibodies passive immunization |
| url | http://www.mdpi.com/2076-2607/6/1/25 |
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