ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID
Study of the anti-arrhythmic influence of the new organic synthesis’s products was the purpose of an actual research. Such characteristics of these compounds as acute toxicity, anti-arrhythmic and pro-arrhythmic activity were studied. The mostly strongly marked effect was discovered while using M-0...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/436 |
| _version_ | 1797875034270728192 |
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| author | I. P. Rudakova O. V. Gashkova |
| author_facet | I. P. Rudakova O. V. Gashkova |
| author_sort | I. P. Rudakova |
| collection | DOAJ |
| description | Study of the anti-arrhythmic influence of the new organic synthesis’s products was the purpose of an actual research. Such characteristics of these compounds as acute toxicity, anti-arrhythmic and pro-arrhythmic activity were studied. The mostly strongly marked effect was discovered while using M-0 and M-18. These compounds showed the highest anti-arrhythmic activity and the lowest toxicity. It was also discovered that M-18 compound is less dangerous than M-0 one due to absence of the certainly expressed spill-over effect of an arrhythmogenic action. |
| first_indexed | 2024-04-10T01:40:13Z |
| format | Article |
| id | doaj.art-5b9f72e7852c4248b09f54df679c6de7 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:13Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-5b9f72e7852c4248b09f54df679c6de72023-03-13T09:13:58ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102242245436ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACIDI. P. Rudakova0O. V. Gashkova1ФГБОУ ВО «Пермская государственная фармацевтическая академия» Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России)ФГБОУ ВО «Пермская государственная фармацевтическая академия» Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России)Study of the anti-arrhythmic influence of the new organic synthesis’s products was the purpose of an actual research. Such characteristics of these compounds as acute toxicity, anti-arrhythmic and pro-arrhythmic activity were studied. The mostly strongly marked effect was discovered while using M-0 and M-18. These compounds showed the highest anti-arrhythmic activity and the lowest toxicity. It was also discovered that M-18 compound is less dangerous than M-0 one due to absence of the certainly expressed spill-over effect of an arrhythmogenic action.https://www.pharmjournal.ru/jour/article/view/436аритмияострая токсичностьэффективная антиаритмическая дозааритмогенный эффект |
| spellingShingle | I. P. Rudakova O. V. Gashkova ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID Разработка и регистрация лекарственных средств аритмия острая токсичность эффективная антиаритмическая доза аритмогенный эффект |
| title | ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID |
| title_full | ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID |
| title_fullStr | ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID |
| title_full_unstemmed | ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID |
| title_short | ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID |
| title_sort | assessment of antiarrhythmic activity and safety of new derivatives of morpholinoacetic acid |
| topic | аритмия острая токсичность эффективная антиаритмическая доза аритмогенный эффект |
| url | https://www.pharmjournal.ru/jour/article/view/436 |
| work_keys_str_mv | AT iprudakova assessmentofantiarrhythmicactivityandsafetyofnewderivativesofmorpholinoaceticacid AT ovgashkova assessmentofantiarrhythmicactivityandsafetyofnewderivativesofmorpholinoaceticacid |