Overexpression of alpha‐1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice

Overexpression of alpha‐1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice

Abstract Islet/β cell dysfunction and death caused by autoimmune‐mediated injuries are major features of type 1 diabetes (T1D). Mesenchymal stromal cells (MSCs) have been used for the treatment of T1D in animal models and clinical trials. Based on the anti‐inflammatory effects of alpha‐1 antitrypsin...

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Bibliographic Details
Main Authors: Lili Song, Wenyu Gou, Jingjing Wang, Hua Wei, Jennifer Lee, Charlie Strange, Hongjun Wang
Format: Article
Language:English
Published: Oxford University Press 2021-02-01
Series:Stem Cells Translational Medicine
Subjects:
diabetes onset
human α‐1 antitrypsin
mesenchymal stromal cells
stemness
type 1 diabetes
Online Access:https://doi.org/10.1002/sctm.20-0122

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