Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine
Abstract Background A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study is to investigate the modulation effect of taVNS frequency on the desce...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-03024-9 |
| _version_ | 1819124809531916288 |
|---|---|
| author | Jin Cao Yue Zhang Hui Li Zhaoxian Yan Xian Liu Xiaoyan Hou Weicui Chen Sierra Hodges Jian Kong Bo Liu |
| author_facet | Jin Cao Yue Zhang Hui Li Zhaoxian Yan Xian Liu Xiaoyan Hou Weicui Chen Sierra Hodges Jian Kong Bo Liu |
| author_sort | Jin Cao |
| collection | DOAJ |
| description | Abstract Background A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study is to investigate the modulation effect of taVNS frequency on the descending pain modulation system (DPMS) in patients with migraine. Methods Twenty-four episodic migraineurs without aura (21 females) were recruited for the single-blind, crossover, functional magnetic resonance imaging (fMRI) study. Each participant attended two separate fMRI scan sessions, one for 1 Hz and another for 20 Hz taVNS, in a random order. Seed-based functional connectivity analysis was applied using the ventrolateral periaqueductal gray (PAG) as the region of interest. Results Compared with the pre-taVNS resting state, continuous 1 Hz taVNS (during) produced a significant increase in functional connectivity between the PAG and the bilateral middle cingulate cortex (MCC), right precuneus, left middle frontal gyrus (MFG), and left cuneus. Compared with 20 Hz taVNS, 1 Hz taVNS produced greater PAG connectivity increases with the MCC, right precuneus/posterior cingulate cortex, left insula, and anterior cingulate cortex (ACC). A significant negative correlation was observed between the number of migraine attacks in the previous 4 weeks and the PAG-MCC functional connectivity in the pre-taVNS resting-state before 1 Hz taVNS. Conclusions Our findings suggest that taVNS with different frequencies may produce different modulation effects on the descending pain modulation system, demonstrating the important role of stimulation frequency in taVNS treatment. |
| first_indexed | 2024-12-22T07:30:09Z |
| format | Article |
| id | doaj.art-5ba1833d001f4687b7b8d1b04541e64a |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-22T07:30:09Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-5ba1833d001f4687b7b8d1b04541e64a2022-12-21T18:34:03ZengBMCJournal of Translational Medicine1479-58762021-08-0119111110.1186/s12967-021-03024-9Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraineJin Cao0Yue Zhang1Hui Li2Zhaoxian Yan3Xian Liu4Xiaoyan Hou5Weicui Chen6Sierra Hodges7Jian Kong8Bo Liu9Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese MedicineAbstract Background A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study is to investigate the modulation effect of taVNS frequency on the descending pain modulation system (DPMS) in patients with migraine. Methods Twenty-four episodic migraineurs without aura (21 females) were recruited for the single-blind, crossover, functional magnetic resonance imaging (fMRI) study. Each participant attended two separate fMRI scan sessions, one for 1 Hz and another for 20 Hz taVNS, in a random order. Seed-based functional connectivity analysis was applied using the ventrolateral periaqueductal gray (PAG) as the region of interest. Results Compared with the pre-taVNS resting state, continuous 1 Hz taVNS (during) produced a significant increase in functional connectivity between the PAG and the bilateral middle cingulate cortex (MCC), right precuneus, left middle frontal gyrus (MFG), and left cuneus. Compared with 20 Hz taVNS, 1 Hz taVNS produced greater PAG connectivity increases with the MCC, right precuneus/posterior cingulate cortex, left insula, and anterior cingulate cortex (ACC). A significant negative correlation was observed between the number of migraine attacks in the previous 4 weeks and the PAG-MCC functional connectivity in the pre-taVNS resting-state before 1 Hz taVNS. Conclusions Our findings suggest that taVNS with different frequencies may produce different modulation effects on the descending pain modulation system, demonstrating the important role of stimulation frequency in taVNS treatment.https://doi.org/10.1186/s12967-021-03024-9Transcutaneous auricular vagus nerve stimulationFunctional connectivityPeriaqueductal grayDescending pain modulation networkFrequency |
| spellingShingle | Jin Cao Yue Zhang Hui Li Zhaoxian Yan Xian Liu Xiaoyan Hou Weicui Chen Sierra Hodges Jian Kong Bo Liu Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine Journal of Translational Medicine Transcutaneous auricular vagus nerve stimulation Functional connectivity Periaqueductal gray Descending pain modulation network Frequency |
| title | Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| title_full | Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| title_fullStr | Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| title_full_unstemmed | Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| title_short | Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| title_sort | different modulation effects of 1 hz and 20 hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine |
| topic | Transcutaneous auricular vagus nerve stimulation Functional connectivity Periaqueductal gray Descending pain modulation network Frequency |
| url | https://doi.org/10.1186/s12967-021-03024-9 |
| work_keys_str_mv | AT jincao differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT yuezhang differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT huili differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT zhaoxianyan differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT xianliu differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT xiaoyanhou differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT weicuichen differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT sierrahodges differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT jiankong differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine AT boliu differentmodulationeffectsof1hzand20hztranscutaneousauricularvagusnervestimulationonthefunctionalconnectivityoftheperiaqueductalgrayinpatientswithmigraine |