Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway. TAAR1 is involved in the effects of addictive drugs, such as amphetamines, cocaine and ethanol, but the impact of TAAR1 on the effe...
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| Format: | Article |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00329/full |
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| author | Ilya Sukhanov Ilya Sukhanov Ilya Sukhanov Mariia Dorofeikova Antonina Dolgorukova Artem Dorotenko Raul R. Gainetdinov Raul R. Gainetdinov |
| author_facet | Ilya Sukhanov Ilya Sukhanov Ilya Sukhanov Mariia Dorofeikova Antonina Dolgorukova Artem Dorotenko Raul R. Gainetdinov Raul R. Gainetdinov |
| author_sort | Ilya Sukhanov |
| collection | DOAJ |
| description | Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway. TAAR1 is involved in the effects of addictive drugs, such as amphetamines, cocaine and ethanol, but the impact of TAAR1 on the effects of nicotine, the psychoactive drug responsible for the development and maintenance of tobacco smoking, has not yet been studied. This study was performed to investigate the possible modulatory action of TAAR1 on the effects of nicotine on locomotor behaviors in rats and mice. Pretreatment with the TAAR1 agonist RO5263397 dose-dependently decreased nicotine-induced hyperlocomotion in rats habituated to locomotor boxes, prevented the development of nicotine sensitization and blocked hypermotility in nicotine-sensitized rats at the highest tested dose (10 mg/kg). The lack of TAAR1 failed to affect the effects of nicotine on the locomotion of mutant mice. Based on the results of the present study, TAAR1 activation attenuates the locomotion-stimulating effects of nicotine on rats. These results further support the previously proposed hypothesis that TAAR1 is a promising target for the prevention and treatment of drug addiction. Further studies aimed at analyzing the effects of TAAR1 agonists on animal models of nicotine addiction are warranted. |
| first_indexed | 2024-12-12T12:27:26Z |
| format | Article |
| id | doaj.art-5ba2a21b7a26443fa320f8de21eb708c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T12:27:26Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5ba2a21b7a26443fa320f8de21eb708c2022-12-22T00:24:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-04-01910.3389/fphar.2018.00329341972Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of NicotineIlya Sukhanov0Ilya Sukhanov1Ilya Sukhanov2Mariia Dorofeikova3Antonina Dolgorukova4Artem Dorotenko5Raul R. Gainetdinov6Raul R. Gainetdinov7Laboratory of Behavioral Pharmacology, Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaLaboratory of Neurochemical Pharmacology, Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Technologia, Genoa, ItalyInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, RussiaLaboratory of Behavioral Pharmacology, Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaLaboratory of Behavioral Pharmacology, Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaLaboratory of Behavioral Pharmacology, Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, RussiaSkolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow, RussiaTrace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway. TAAR1 is involved in the effects of addictive drugs, such as amphetamines, cocaine and ethanol, but the impact of TAAR1 on the effects of nicotine, the psychoactive drug responsible for the development and maintenance of tobacco smoking, has not yet been studied. This study was performed to investigate the possible modulatory action of TAAR1 on the effects of nicotine on locomotor behaviors in rats and mice. Pretreatment with the TAAR1 agonist RO5263397 dose-dependently decreased nicotine-induced hyperlocomotion in rats habituated to locomotor boxes, prevented the development of nicotine sensitization and blocked hypermotility in nicotine-sensitized rats at the highest tested dose (10 mg/kg). The lack of TAAR1 failed to affect the effects of nicotine on the locomotion of mutant mice. Based on the results of the present study, TAAR1 activation attenuates the locomotion-stimulating effects of nicotine on rats. These results further support the previously proposed hypothesis that TAAR1 is a promising target for the prevention and treatment of drug addiction. Further studies aimed at analyzing the effects of TAAR1 agonists on animal models of nicotine addiction are warranted.http://journal.frontiersin.org/article/10.3389/fphar.2018.00329/fullTAAR1nicotinedopaminedrug addictionsensitizationlocomotor activity |
| spellingShingle | Ilya Sukhanov Ilya Sukhanov Ilya Sukhanov Mariia Dorofeikova Antonina Dolgorukova Artem Dorotenko Raul R. Gainetdinov Raul R. Gainetdinov Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine Frontiers in Pharmacology TAAR1 nicotine dopamine drug addiction sensitization locomotor activity |
| title | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine |
| title_full | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine |
| title_fullStr | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine |
| title_full_unstemmed | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine |
| title_short | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine |
| title_sort | trace amine associated receptor 1 modulates the locomotor and sensitization effects of nicotine |
| topic | TAAR1 nicotine dopamine drug addiction sensitization locomotor activity |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00329/full |
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