Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine

Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine

Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway. TAAR1 is involved in the effects of addictive drugs, such as amphetamines, cocaine and ethanol, but the impact of TAAR1 on the effe...

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Bibliographic Details
Main Authors: Ilya Sukhanov, Mariia Dorofeikova, Antonina Dolgorukova, Artem Dorotenko, Raul R. Gainetdinov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
TAAR1
nicotine
dopamine
drug addiction
sensitization
locomotor activity
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00329/full

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