Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants
Atrial fibrillation (AF) is the most common arrhythmia, ranging from 0.1% in patients <55 years to >9% in octogenarian patients. One important issue is represented by the 5-fold increased ischemic stroke risk in AF patients. Hence, the role of anticoagulation is central. Until a few ye...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/10/617 |
| _version_ | 1797728688270213120 |
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| author | Alfredo Caturano Raffaele Galiero Pia Clara Pafundi |
| author_facet | Alfredo Caturano Raffaele Galiero Pia Clara Pafundi |
| author_sort | Alfredo Caturano |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common arrhythmia, ranging from 0.1% in patients <55 years to >9% in octogenarian patients. One important issue is represented by the 5-fold increased ischemic stroke risk in AF patients. Hence, the role of anticoagulation is central. Until a few years ago, vitamin K antagonists (VKAs) and low molecular weight heparin represented the only option to prevent thromboembolisms, though with risks. Novel oral anticoagulants (NOACs) have radically changed the management of AF patients, improving both life expectancy and life quality. This review aims to summarize the most recent literature on the use of VKAs and NOACs in AF, in light of the new findings. |
| first_indexed | 2024-03-12T11:17:37Z |
| format | Article |
| id | doaj.art-5ba476ac7fde45bc8ecb60911605de7e |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:17:37Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5ba476ac7fde45bc8ecb60911605de7e2023-09-02T01:47:24ZengMDPI AGMedicina1010-660X2019-09-01551061710.3390/medicina55100617medicina55100617Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral AnticoagulantsAlfredo Caturano0Raffaele Galiero1Pia Clara Pafundi2Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 2, IT-80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 2, IT-80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 2, IT-80138 Naples, ItalyAtrial fibrillation (AF) is the most common arrhythmia, ranging from 0.1% in patients <55 years to >9% in octogenarian patients. One important issue is represented by the 5-fold increased ischemic stroke risk in AF patients. Hence, the role of anticoagulation is central. Until a few years ago, vitamin K antagonists (VKAs) and low molecular weight heparin represented the only option to prevent thromboembolisms, though with risks. Novel oral anticoagulants (NOACs) have radically changed the management of AF patients, improving both life expectancy and life quality. This review aims to summarize the most recent literature on the use of VKAs and NOACs in AF, in light of the new findings.https://www.mdpi.com/1010-660X/55/10/617NOACsnon vitamin K oral anticoagulantsatrial fibrillationstrokeoral anticoagulation |
| spellingShingle | Alfredo Caturano Raffaele Galiero Pia Clara Pafundi Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants Medicina NOACs non vitamin K oral anticoagulants atrial fibrillation stroke oral anticoagulation |
| title | Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants |
| title_full | Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants |
| title_fullStr | Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants |
| title_full_unstemmed | Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants |
| title_short | Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants |
| title_sort | atrial fibrillation and stroke a review on the use of vitamin k antagonists and novel oral anticoagulants |
| topic | NOACs non vitamin K oral anticoagulants atrial fibrillation stroke oral anticoagulation |
| url | https://www.mdpi.com/1010-660X/55/10/617 |
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