Role of inflammatory cells in airway remodeling in COPD
Yujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; 3Cell and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-10-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/role-of-inflammatory-cells-in-airway-remodeling-in-copd-peer-reviewed-article-COPD |
| _version_ | 1831838529920958464 |
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| author | Wang Y Xu J Meng Y Adcock IM Yao X |
| author_facet | Wang Y Xu J Meng Y Adcock IM Yao X |
| author_sort | Wang Y |
| collection | DOAJ |
| description | Yujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; 3Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK Abstract: COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD. Chronic inflammation in COPD mainly involves the infiltration of neutrophils, macrophages, lymphocytes, and other inflammatory cells into the small airways. The contribution of resident airway structural cells to the inflammatory process is also important in COPD. Airway remodeling consists of detrimental changes in structural tissues and cells including airway wall thickening, epithelial metaplasia, goblet cell hypertrophy, and smooth muscle hyperplasia. Persistent airway inflammation might contribute to airway remodeling and small airway obstruction. However, the underlying mechanisms remain unclear. In this review, we will provide an overview of recent insights into the role of major immunoinflammatory cells in COPD airway remodeling. Keywords: COPD, airway inflammation, airway remodeling |
| first_indexed | 2024-12-23T05:35:18Z |
| format | Article |
| id | doaj.art-5ba4a852120d4aa6816239c92742fcea |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-23T05:35:18Z |
| publishDate | 2018-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-5ba4a852120d4aa6816239c92742fcea2022-12-21T17:58:21ZengDove Medical PressInternational Journal of COPD1178-20052018-10-01Volume 133341334841394Role of inflammatory cells in airway remodeling in COPDWang YXu JMeng YAdcock IMYao XYujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; 3Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK Abstract: COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD. Chronic inflammation in COPD mainly involves the infiltration of neutrophils, macrophages, lymphocytes, and other inflammatory cells into the small airways. The contribution of resident airway structural cells to the inflammatory process is also important in COPD. Airway remodeling consists of detrimental changes in structural tissues and cells including airway wall thickening, epithelial metaplasia, goblet cell hypertrophy, and smooth muscle hyperplasia. Persistent airway inflammation might contribute to airway remodeling and small airway obstruction. However, the underlying mechanisms remain unclear. In this review, we will provide an overview of recent insights into the role of major immunoinflammatory cells in COPD airway remodeling. Keywords: COPD, airway inflammation, airway remodelinghttps://www.dovepress.com/role-of-inflammatory-cells-in-airway-remodeling-in-copd-peer-reviewed-article-COPDChronic obstructive pulmonary disease (COPD)airway inflammationairway remodeling |
| spellingShingle | Wang Y Xu J Meng Y Adcock IM Yao X Role of inflammatory cells in airway remodeling in COPD International Journal of COPD Chronic obstructive pulmonary disease (COPD) airway inflammation airway remodeling |
| title | Role of inflammatory cells in airway remodeling in COPD |
| title_full | Role of inflammatory cells in airway remodeling in COPD |
| title_fullStr | Role of inflammatory cells in airway remodeling in COPD |
| title_full_unstemmed | Role of inflammatory cells in airway remodeling in COPD |
| title_short | Role of inflammatory cells in airway remodeling in COPD |
| title_sort | role of inflammatory cells in airway remodeling in copd |
| topic | Chronic obstructive pulmonary disease (COPD) airway inflammation airway remodeling |
| url | https://www.dovepress.com/role-of-inflammatory-cells-in-airway-remodeling-in-copd-peer-reviewed-article-COPD |
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