Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats
The present study explored the antihyperlipidemic potential of a standardized methanolic extract of <i>Averrhoa carambola</i> (<i>A. carambola</i>) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1...
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MDPI AG
2019-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/7/3/72 |
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| author | Saleem H. Aladaileh Sultan A. M. Saghir Kisantini Murugesu Amirin Sadikun Ashfaq Ahmad Gurjeet Kaur Ayman M. Mahmoud Vikneswaran Murugaiyah |
| author_facet | Saleem H. Aladaileh Sultan A. M. Saghir Kisantini Murugesu Amirin Sadikun Ashfaq Ahmad Gurjeet Kaur Ayman M. Mahmoud Vikneswaran Murugaiyah |
| author_sort | Saleem H. Aladaileh |
| collection | DOAJ |
| description | The present study explored the antihyperlipidemic potential of a standardized methanolic extract of <i>Averrhoa carambola</i> (<i>A. carambola</i>) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase. |
| first_indexed | 2024-12-16T12:58:02Z |
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| language | English |
| last_indexed | 2024-12-16T12:58:02Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5ba6b68ab61e44bcb28018ce305b37ed2022-12-21T22:30:56ZengMDPI AGBiomedicines2227-90592019-09-01737210.3390/biomedicines7030072biomedicines7030072Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed RatsSaleem H. Aladaileh0Sultan A. M. Saghir1Kisantini Murugesu2Amirin Sadikun3Ashfaq Ahmad4Gurjeet Kaur5Ayman M. Mahmoud6Vikneswaran Murugaiyah7Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma`an 71111, JordanDepartment of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma`an 71111, JordanDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaDepartment of Pharmacology and Toxicology, Virginia CommonWealth University, Richmond, VA 23284, USAInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pinang 11800, MalaysiaPhysiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaThe present study explored the antihyperlipidemic potential of a standardized methanolic extract of <i>Averrhoa carambola</i> (<i>A. carambola</i>) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase.https://www.mdpi.com/2227-9059/7/3/72<i>Averrhoa</i> <i>carambola</i>dyslipidemiahigh-fat dietHMG-CoAoxidative stress |
| spellingShingle | Saleem H. Aladaileh Sultan A. M. Saghir Kisantini Murugesu Amirin Sadikun Ashfaq Ahmad Gurjeet Kaur Ayman M. Mahmoud Vikneswaran Murugaiyah Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats Biomedicines <i>Averrhoa</i> <i>carambola</i> dyslipidemia high-fat diet HMG-CoA oxidative stress |
| title | Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats |
| title_full | Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats |
| title_fullStr | Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats |
| title_full_unstemmed | Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats |
| title_short | Antihyperlipidemic and Antioxidant Effects of <em>Averrhoa</em> <em>Carambola</em> Extract in High-Fat Diet-Fed Rats |
| title_sort | antihyperlipidemic and antioxidant effects of em averrhoa em em carambola em extract in high fat diet fed rats |
| topic | <i>Averrhoa</i> <i>carambola</i> dyslipidemia high-fat diet HMG-CoA oxidative stress |
| url | https://www.mdpi.com/2227-9059/7/3/72 |
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