MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?
Abstract Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA degradation or translation repression. Recent studies suggest that miR-296 may play...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-03-01
|
| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10020-018-0012-y |
| _version_ | 1818282160300228608 |
|---|---|
| author | Heng Li Xin-Ping Ouyang Ting Jiang Xi-Long Zheng Ping-Ping He Guo-Jun Zhao |
| author_facet | Heng Li Xin-Ping Ouyang Ting Jiang Xi-Long Zheng Ping-Ping He Guo-Jun Zhao |
| author_sort | Heng Li |
| collection | DOAJ |
| description | Abstract Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA degradation or translation repression. Recent studies suggest that miR-296 may play crucial roles in the regulation of angiogenesis, inflammatory response, cholesterol metabolism, hypertension, cellular proliferation and apoptosis. In this review, we primarily discussed the molecular targets of miR-296 involved in the development of atherosclerosis, which may provide a basis for future investigation and a better understanding of the biological functions of miR-296 in atherosclerosis. |
| first_indexed | 2024-12-13T00:16:36Z |
| format | Article |
| id | doaj.art-5ba84e6ab29b47dc9c9436f333b9f805 |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-12-13T00:16:36Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-5ba84e6ab29b47dc9c9436f333b9f8052022-12-22T00:05:46ZengBMCMolecular Medicine1076-15511528-36582018-03-012411810.1186/s10020-018-0012-yMicroRNA-296: a promising target in the pathogenesis of atherosclerosis?Heng Li0Xin-Ping Ouyang1Ting Jiang2Xi-Long Zheng3Ping-Ping He4Guo-Jun Zhao5The Clinic Medical College, Guilin Medical UniversityHunan Province Cooperative innovation Center for Molecular Target New Drug StudyDepartment of Practice educational, Office of Academic Affairs, Guilin Medical UniversityDepartment of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences CenterHunan Province Cooperative innovation Center for Molecular Target New Drug StudyDepartment of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences CenterAbstract Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA degradation or translation repression. Recent studies suggest that miR-296 may play crucial roles in the regulation of angiogenesis, inflammatory response, cholesterol metabolism, hypertension, cellular proliferation and apoptosis. In this review, we primarily discussed the molecular targets of miR-296 involved in the development of atherosclerosis, which may provide a basis for future investigation and a better understanding of the biological functions of miR-296 in atherosclerosis.http://link.springer.com/article/10.1186/s10020-018-0012-ymiR-296AngiogenesisInflammationAtherosclerosis |
| spellingShingle | Heng Li Xin-Ping Ouyang Ting Jiang Xi-Long Zheng Ping-Ping He Guo-Jun Zhao MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? Molecular Medicine miR-296 Angiogenesis Inflammation Atherosclerosis |
| title | MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? |
| title_full | MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? |
| title_fullStr | MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? |
| title_full_unstemmed | MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? |
| title_short | MicroRNA-296: a promising target in the pathogenesis of atherosclerosis? |
| title_sort | microrna 296 a promising target in the pathogenesis of atherosclerosis |
| topic | miR-296 Angiogenesis Inflammation Atherosclerosis |
| url | http://link.springer.com/article/10.1186/s10020-018-0012-y |
| work_keys_str_mv | AT hengli microrna296apromisingtargetinthepathogenesisofatherosclerosis AT xinpingouyang microrna296apromisingtargetinthepathogenesisofatherosclerosis AT tingjiang microrna296apromisingtargetinthepathogenesisofatherosclerosis AT xilongzheng microrna296apromisingtargetinthepathogenesisofatherosclerosis AT pingpinghe microrna296apromisingtargetinthepathogenesisofatherosclerosis AT guojunzhao microrna296apromisingtargetinthepathogenesisofatherosclerosis |