Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome

Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome

Abstract Background Large palindromes (inverted repeats) make up substantial proportions of mammalian sex chromosomes, often contain genes, and have high rates of structural variation arising via ectopic recombination. As a result, they underlie many genomic disorders. Maintenance of the palindromic...

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Bibliographic Details
Main Authors: Wentao Shi, Andrea Massaia, Sandra Louzada, Juliet Handsaker, William Chow, Shane McCarthy, Joanna Collins, Pille Hallast, Kerstin Howe, Deanna M. Church, Fengtang Yang, Yali Xue, Chris Tyler-Smith
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Biology
Subjects:
Structural variation
Copy number variation
Inverted repeat
Sex chromosome
Variable Charge Y gene
Online Access:http://link.springer.com/article/10.1186/s13059-019-1816-y

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