Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats
Anesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery. Beyond being an anesthetic used for general anesthesia and sedation, intravenous hypnotic propofol displays a...
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/14/3229 |
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| author | Chih-Cheng Wu Chih-Jen Hung Ya-Yu Wang Shih-Yi Lin Wen-Ying Chen Yu-Hsiang Kuan Su-Lan Liao Ching-Ping Yang Chun-Jung Chen |
| author_facet | Chih-Cheng Wu Chih-Jen Hung Ya-Yu Wang Shih-Yi Lin Wen-Ying Chen Yu-Hsiang Kuan Su-Lan Liao Ching-Ping Yang Chun-Jung Chen |
| author_sort | Chih-Cheng Wu |
| collection | DOAJ |
| description | Anesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery. Beyond being an anesthetic used for general anesthesia and sedation, intravenous hypnotic propofol displays an effect on glucose metabolism. To extend the scope of propofol studies, its effects on glucose metabolism were evaluated in male Sprague-Dawley rats of various ages. Unlike chloral hydrate and isoflurane, propofol had little effect on basal glucose levels in rats at 2 months of age, although it did reduce chloral hydrate- and isoflurane-induced hyperglycemia. Propofol reduced postload glucose levels after either intraperitoneal or oral administration of glucose in both 7- and 12-month-old rats, but not those at 2 months of age. These improved effects regarding propofol on glucose metabolism were accompanied by an increase in insulin, fibroblast growth factor-21 (FGF-21), and glucagon-like peptide-1 (GLP-1) secretion. Additionally, an increase in hepatic FGF-21 expression, GLP-1 signaling, and FGF-21 signaling, along with a decrease in endoplasmic reticulum (ER) stress, were noted in propofol-treated rats at 7 months of age. Current findings imply that propofol may turn into insulin-sensitizing molecules during situations of existing insulin resistance, which involve FGF-21, GLP-1, and ER stress. |
| first_indexed | 2024-03-10T18:27:36Z |
| format | Article |
| id | doaj.art-5babfeb87c2148feb536c2d97c56a507 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:27:36Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5babfeb87c2148feb536c2d97c56a5072023-11-20T06:51:35ZengMDPI AGMolecules1420-30492020-07-012514322910.3390/molecules25143229Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley RatsChih-Cheng Wu0Chih-Jen Hung1Ya-Yu Wang2Shih-Yi Lin3Wen-Ying Chen4Yu-Hsiang Kuan5Su-Lan Liao6Ching-Ping Yang7Chun-Jung Chen8Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, TaiwanDepartment of Anesthesiology, Taichung Veterans General Hospital, Taichung City 407, TaiwanDepartment of Family Medicine, Taichung Veterans General Hospital, Taichung City 407, TaiwanInstitute of Clinical Medicine, National Yang Ming University, Taipei City 112, TaiwanDepartment of Veterinary Medicine, National Chung-Hsing University, Taichung City 402, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung City 402, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung City 407, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung City 407, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung City 407, TaiwanAnesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery. Beyond being an anesthetic used for general anesthesia and sedation, intravenous hypnotic propofol displays an effect on glucose metabolism. To extend the scope of propofol studies, its effects on glucose metabolism were evaluated in male Sprague-Dawley rats of various ages. Unlike chloral hydrate and isoflurane, propofol had little effect on basal glucose levels in rats at 2 months of age, although it did reduce chloral hydrate- and isoflurane-induced hyperglycemia. Propofol reduced postload glucose levels after either intraperitoneal or oral administration of glucose in both 7- and 12-month-old rats, but not those at 2 months of age. These improved effects regarding propofol on glucose metabolism were accompanied by an increase in insulin, fibroblast growth factor-21 (FGF-21), and glucagon-like peptide-1 (GLP-1) secretion. Additionally, an increase in hepatic FGF-21 expression, GLP-1 signaling, and FGF-21 signaling, along with a decrease in endoplasmic reticulum (ER) stress, were noted in propofol-treated rats at 7 months of age. Current findings imply that propofol may turn into insulin-sensitizing molecules during situations of existing insulin resistance, which involve FGF-21, GLP-1, and ER stress.https://www.mdpi.com/1420-3049/25/14/3229anestheticshyperglycemiainsulin resistancepropofol |
| spellingShingle | Chih-Cheng Wu Chih-Jen Hung Ya-Yu Wang Shih-Yi Lin Wen-Ying Chen Yu-Hsiang Kuan Su-Lan Liao Ching-Ping Yang Chun-Jung Chen Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats Molecules anesthetics hyperglycemia insulin resistance propofol |
| title | Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats |
| title_full | Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats |
| title_fullStr | Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats |
| title_full_unstemmed | Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats |
| title_short | Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats |
| title_sort | propofol improved glucose tolerance associated with increased fgf 21 and glp 1 production in male sprague dawley rats |
| topic | anesthetics hyperglycemia insulin resistance propofol |
| url | https://www.mdpi.com/1420-3049/25/14/3229 |
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