A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis
Abstract Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. This knowledge gap has resulted in ineffective biomarker development and suboptimal treatment regimens to prevent and manage organ dysfuncti...
Main Authors: | Tirthankar Mohanty, Christofer A. Q. Karlsson, Yashuan Chao, Erik Malmström, Eleni Bratanis, Andrietta Grentzmann, Martina Mørch, Victor Nizet, Lars Malmström, Adam Linder, Oonagh Shannon, Johan Malmström |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-39269-9 |
Similar Items
-
Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis
by: Erik Hartman, et al.
Published: (2023-09-01) -
Generalized precursor prediction boosts identification rates and accuracy in mass spectrometry based proteomics
by: Aaron M. Scott, et al.
Published: (2023-06-01) -
Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics
by: Erik Malmström, et al.
Published: (2016-01-01) -
Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis
by: Anahita Bakochi, et al.
Published: (2021-04-01) -
Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections
by: Alejandro Gomez Toledo, et al.
Published: (2023-10-01)