Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study
Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi-center retrospective observational cohort study wa...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00479/full |
| _version_ | 1811225052521168896 |
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| author | Luca Filippi Giacomo Cavallaro Lavinia Perciasepe Elena Sandini Gabriella Araimo Giulia Regiroli Giulia Regiroli Genny Raffaeli Paola Bagnoli Massimo Dal Monte Maura Calvani Pina Fortunato Silvia Osnaghi Salvatore De Masi Fabio Mosca Fabio Mosca |
| author_facet | Luca Filippi Giacomo Cavallaro Lavinia Perciasepe Elena Sandini Gabriella Araimo Giulia Regiroli Giulia Regiroli Genny Raffaeli Paola Bagnoli Massimo Dal Monte Maura Calvani Pina Fortunato Silvia Osnaghi Salvatore De Masi Fabio Mosca Fabio Mosca |
| author_sort | Luca Filippi |
| collection | DOAJ |
| description | Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi-center retrospective observational cohort study was conducted to assess the physical development and the refractive outcome of infants with prior ROP treated with propranolol. Forty-nine infants treated with propranolol were compared with an equal number of patients who did not receive any propranolol therapy and represent the control group, with comparable anthropometrical characteristics and stages of ROP.Results: The weight, length, and head circumference at 1 year of corrected age were similar between infants who had been treated, or not, with propranolol, without any statistically significant differences. Refractive evaluation at 1 year showed spherical equivalent values decreasing with the progression of ROP toward more severe stages of the disease, together with an increasing number of infants with severe myopia. On the contrary, no differences were observed between infants who had been treated with propranolol and those who had not.Conclusion: This study confirms that the progression of ROP induces an increase of refractive errors and suggests that propranolol itself does not affect the refractive outcome. Therefore, if the efficacy of propranolol in counteracting ROP progression is confirmed by further clinical trials, the conclusion will be that propranolol might indirectly improve the visual outcome, reducing the progression of ROP. |
| first_indexed | 2024-04-12T08:59:19Z |
| format | Article |
| id | doaj.art-5bada152724b449e9b42959a481d461e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T08:59:19Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-5bada152724b449e9b42959a481d461e2022-12-22T03:39:17ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-11-01710.3389/fped.2019.00479489085Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort StudyLuca Filippi0Giacomo Cavallaro1Lavinia Perciasepe2Elena Sandini3Gabriella Araimo4Giulia Regiroli5Giulia Regiroli6Genny Raffaeli7Paola Bagnoli8Massimo Dal Monte9Maura Calvani10Pina Fortunato11Silvia Osnaghi12Salvatore De Masi13Fabio Mosca14Fabio Mosca15Neonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, “A. Meyer” University Children's Hospital, Florence, ItalyNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, “A. Meyer” University Children's Hospital, Florence, ItalyNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, “A. Meyer” University Children's Hospital, Florence, ItalyNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, Milan, ItalyNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyUnit of General Physiology, Department of Biology, University of Pisa, Pisa, ItalyUnit of General Physiology, Department of Biology, University of Pisa, Pisa, ItalyOncohematology Unit, Department of Pediatric Oncology, “A. Meyer” University Children's Hospital, Florence, ItalyPediatric Ophthalmology, A. Meyer” University Children's Hospital, Florence, ItalyDepartment of Ophthalmology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, ItalyClinical Trial Office, “A. Meyer” University Children's Hospital, Florence, ItalyNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, Milan, ItalyBackground: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi-center retrospective observational cohort study was conducted to assess the physical development and the refractive outcome of infants with prior ROP treated with propranolol. Forty-nine infants treated with propranolol were compared with an equal number of patients who did not receive any propranolol therapy and represent the control group, with comparable anthropometrical characteristics and stages of ROP.Results: The weight, length, and head circumference at 1 year of corrected age were similar between infants who had been treated, or not, with propranolol, without any statistically significant differences. Refractive evaluation at 1 year showed spherical equivalent values decreasing with the progression of ROP toward more severe stages of the disease, together with an increasing number of infants with severe myopia. On the contrary, no differences were observed between infants who had been treated with propranolol and those who had not.Conclusion: This study confirms that the progression of ROP induces an increase of refractive errors and suggests that propranolol itself does not affect the refractive outcome. Therefore, if the efficacy of propranolol in counteracting ROP progression is confirmed by further clinical trials, the conclusion will be that propranolol might indirectly improve the visual outcome, reducing the progression of ROP.https://www.frontiersin.org/article/10.3389/fped.2019.00479/fullpropranololbeta-blockerproliferative retinopathyangiogenesispreterm newborn |
| spellingShingle | Luca Filippi Giacomo Cavallaro Lavinia Perciasepe Elena Sandini Gabriella Araimo Giulia Regiroli Giulia Regiroli Genny Raffaeli Paola Bagnoli Massimo Dal Monte Maura Calvani Pina Fortunato Silvia Osnaghi Salvatore De Masi Fabio Mosca Fabio Mosca Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study Frontiers in Pediatrics propranolol beta-blocker proliferative retinopathy angiogenesis preterm newborn |
| title | Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study |
| title_full | Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study |
| title_fullStr | Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study |
| title_full_unstemmed | Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study |
| title_short | Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study |
| title_sort | refractive outcome in preterm newborns with rop after propranolol treatment a retrospective observational cohort study |
| topic | propranolol beta-blocker proliferative retinopathy angiogenesis preterm newborn |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00479/full |
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