Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study
Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/5/419 |
| _version_ | 1797533406965268480 |
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| author | Carmen Muntean Maria Săsăran |
| author_facet | Carmen Muntean Maria Săsăran |
| author_sort | Carmen Muntean |
| collection | DOAJ |
| description | Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (<i>p</i> < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (<i>p</i> < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (<i>p</i> = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs. |
| first_indexed | 2024-03-10T11:15:08Z |
| format | Article |
| id | doaj.art-5baee6ac4cf84be794f1630c5ca081d9 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T11:15:08Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-5baee6ac4cf84be794f1630c5ca081d92023-11-21T20:30:27ZengMDPI AGChildren2227-90672021-05-018541910.3390/children8050419Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control StudyCarmen Muntean0Maria Săsăran1Department of Paediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, RomaniaDepartment of Paediatrics III, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, RomaniaVitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (<i>p</i> < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (<i>p</i> < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (<i>p</i> = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.https://www.mdpi.com/2227-9067/8/5/419vitamin Durinary tract infectionschildrenrecurrencedeficiency |
| spellingShingle | Carmen Muntean Maria Săsăran Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study Children vitamin D urinary tract infections children recurrence deficiency |
| title | Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study |
| title_full | Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study |
| title_fullStr | Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study |
| title_full_unstemmed | Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study |
| title_short | Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study |
| title_sort | vitamin d status and its role in first time and recurrent urinary tract infections in children a case control study |
| topic | vitamin D urinary tract infections children recurrence deficiency |
| url | https://www.mdpi.com/2227-9067/8/5/419 |
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