Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions
Chemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses. CIPN can persist post-therapy, and significantly impact the health and quality of life of cancer survi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2022.864910/full |
| _version_ | 1819121129133965312 |
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| author | Rozalyn L. Rodwin Namrah Z. Siddiq Barbara E. Ehrlich Barbara E. Ehrlich Maryam B. Lustberg Maryam B. Lustberg |
| author_facet | Rozalyn L. Rodwin Namrah Z. Siddiq Barbara E. Ehrlich Barbara E. Ehrlich Maryam B. Lustberg Maryam B. Lustberg |
| author_sort | Rozalyn L. Rodwin |
| collection | DOAJ |
| description | Chemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses. CIPN can persist post-therapy, and significantly impact the health and quality of life of cancer survivors. Identifying patients at risk for CIPN is challenging due to the lack of standardized objective measures to assess for CIPN. Furthermore, there are no approved preventative treatments for CIPN, and therapeutic options for CIPN remain limited once it develops. Biomarkers of CIPN have been studied but are not widely used in clinical practice. They can serve as an important clinical tool to identify individuals at risk for CIPN and to better understand the pathogenesis and avenues for treatment of CIPN. Here we review promising biomarkers of CIPN in humans and their clinical implications. |
| first_indexed | 2024-12-22T06:31:39Z |
| format | Article |
| id | doaj.art-5bb01bcf41ef441393fdcefd991cdfdf |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-12-22T06:31:39Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-5bb01bcf41ef441393fdcefd991cdfdf2022-12-21T18:35:42ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2022-03-01310.3389/fpain.2022.864910864910Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future DirectionsRozalyn L. Rodwin0Namrah Z. Siddiq1Barbara E. Ehrlich2Barbara E. Ehrlich3Maryam B. Lustberg4Maryam B. Lustberg5Section of Pediatric Hematology/Oncology, Department of Pediatrics, Yale School of Medicine, New Haven, CT, United StatesSection of Medical Oncology, Department of Medicine, Yale School of Medicine, New Haven, CT, United StatesDepartment of Pharmacology, Yale School of Medicine, New Haven, CT, United StatesYale Cancer Center, New Haven, CT, United StatesSection of Medical Oncology, Department of Medicine, Yale School of Medicine, New Haven, CT, United StatesYale Cancer Center, New Haven, CT, United StatesChemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses. CIPN can persist post-therapy, and significantly impact the health and quality of life of cancer survivors. Identifying patients at risk for CIPN is challenging due to the lack of standardized objective measures to assess for CIPN. Furthermore, there are no approved preventative treatments for CIPN, and therapeutic options for CIPN remain limited once it develops. Biomarkers of CIPN have been studied but are not widely used in clinical practice. They can serve as an important clinical tool to identify individuals at risk for CIPN and to better understand the pathogenesis and avenues for treatment of CIPN. Here we review promising biomarkers of CIPN in humans and their clinical implications.https://www.frontiersin.org/articles/10.3389/fpain.2022.864910/fullchemotherapy-induced peripheral neuropathy (CIPN)paclitaxelvincristinebortezomibbiomarkersoxaliplatin |
| spellingShingle | Rozalyn L. Rodwin Namrah Z. Siddiq Barbara E. Ehrlich Barbara E. Ehrlich Maryam B. Lustberg Maryam B. Lustberg Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions Frontiers in Pain Research chemotherapy-induced peripheral neuropathy (CIPN) paclitaxel vincristine bortezomib biomarkers oxaliplatin |
| title | Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions |
| title_full | Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions |
| title_fullStr | Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions |
| title_full_unstemmed | Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions |
| title_short | Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions |
| title_sort | biomarkers of chemotherapy induced peripheral neuropathy current status and future directions |
| topic | chemotherapy-induced peripheral neuropathy (CIPN) paclitaxel vincristine bortezomib biomarkers oxaliplatin |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2022.864910/full |
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