Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode
The electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2020-12-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/5731 |
| _version_ | 1819203616842448896 |
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| author | Sayed I. M Zayed Yousry M Issa |
| author_facet | Sayed I. M Zayed Yousry M Issa |
| author_sort | Sayed I. M Zayed |
| collection | DOAJ |
| description | The electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled mainly by diffusion. Experimental and instrumental parameters were optimized (50 mV/s scan rate, 50 mV pulse amplitude, and 0.04 mol/L Britton-Robinson (BR) buffer pH 6.50 as a supporting electrolyte) and a sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.17-1.68 µg/mL chlorzoxazone, with detection and quantitation limits of 0.05 and 0.16 µg/mL, respectively. The proposed voltammetric method was successfully applied to the determination of the drug in its pharmaceutical formulation (Myoflex tablets), and in spiked human urine samples. |
| first_indexed | 2024-12-23T04:22:45Z |
| format | Article |
| id | doaj.art-5bb1a25bd6944e0bb06461a4f4d51558 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-23T04:22:45Z |
| publishDate | 2020-12-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-5bb1a25bd6944e0bb06461a4f4d515582022-12-21T18:00:13ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-12-016741053106010.17344/acsi.2020.5731926Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste ElectrodeSayed I. M Zayed0Yousry M Issa1Faculty of Industrial Education, Beni Suef UniversityChemistry Department, Faculty of Science, Cairo UniversityThe electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled mainly by diffusion. Experimental and instrumental parameters were optimized (50 mV/s scan rate, 50 mV pulse amplitude, and 0.04 mol/L Britton-Robinson (BR) buffer pH 6.50 as a supporting electrolyte) and a sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.17-1.68 µg/mL chlorzoxazone, with detection and quantitation limits of 0.05 and 0.16 µg/mL, respectively. The proposed voltammetric method was successfully applied to the determination of the drug in its pharmaceutical formulation (Myoflex tablets), and in spiked human urine samples.https://journals.matheo.si/index.php/ACSi/article/view/5731chlorzoxazonecarbon paste electrodesdifferential pulse anodic voltammetry pharmaceutical dosage formhuman urine samples. |
| spellingShingle | Sayed I. M Zayed Yousry M Issa Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode Acta Chimica Slovenica chlorzoxazone carbon paste electrodes differential pulse anodic voltammetry pharmaceutical dosage form human urine samples. |
| title | Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode |
| title_full | Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode |
| title_fullStr | Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode |
| title_full_unstemmed | Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode |
| title_short | Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode |
| title_sort | differential pulse anodic voltammetric determination of chlorzoxazone in pharmaceutical formulation using carbon paste electrode |
| topic | chlorzoxazone carbon paste electrodes differential pulse anodic voltammetry pharmaceutical dosage form human urine samples. |
| url | https://journals.matheo.si/index.php/ACSi/article/view/5731 |
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