MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions
Drug-resistant epilepsy can be most limiting for patients, and surgery represents a viable therapy option. With the growing research on the human connectome and the evidence of epilepsy being a network disorder, connectivity analysis may be able to contribute to our understanding of epilepsy and may...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/12/1590 |
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| author | Stephan Vogel Martin Kaltenhäuser Cora Kim Nadia Müller-Voggel Karl Rössler Arnd Dörfler Stefan Schwab Hajo Hamer Michael Buchfelder Stefan Rampp |
| author_facet | Stephan Vogel Martin Kaltenhäuser Cora Kim Nadia Müller-Voggel Karl Rössler Arnd Dörfler Stefan Schwab Hajo Hamer Michael Buchfelder Stefan Rampp |
| author_sort | Stephan Vogel |
| collection | DOAJ |
| description | Drug-resistant epilepsy can be most limiting for patients, and surgery represents a viable therapy option. With the growing research on the human connectome and the evidence of epilepsy being a network disorder, connectivity analysis may be able to contribute to our understanding of epilepsy and may be potentially developed into clinical applications. In this magnetoencephalographic study, we determined the whole-brain node degree of connectivity levels in patients and controls. Resting-state activity was measured at five frequency bands in 15 healthy controls and 15 patients with focal epilepsy of different etiologies. The whole-brain all-to-all imaginary part of coherence in source space was then calculated. Node degree was determined and parcellated and was used for further statistical evaluation. In comparison to controls, we found a significantly higher overall node degree in patients with lesional and non-lesional epilepsy. Furthermore, we examined the conditions of high/reduced vigilance and open/closed eyes in controls, to analyze whether patient node degree levels can be achieved. We evaluated intraclass-correlation statistics (ICC) to evaluate the reproducibility. Connectivity and specifically node degree analysis could present new tools for one of the most common neurological diseases, with potential applications in epilepsy diagnostics. |
| first_indexed | 2024-03-09T04:34:52Z |
| format | Article |
| id | doaj.art-5bb42ff9843e4319ae379697371c1f3a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T04:34:52Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-5bb42ff9843e4319ae379697371c1f3a2023-12-03T13:29:23ZengMDPI AGBrain Sciences2076-34252021-11-011112159010.3390/brainsci11121590MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental ConditionsStephan Vogel0Martin Kaltenhäuser1Cora Kim2Nadia Müller-Voggel3Karl Rössler4Arnd Dörfler5Stefan Schwab6Hajo Hamer7Michael Buchfelder8Stefan Rampp9Department of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, Medical University Vienna, 1090 Vienna, AustriaDepartment of Neuroradiology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDrug-resistant epilepsy can be most limiting for patients, and surgery represents a viable therapy option. With the growing research on the human connectome and the evidence of epilepsy being a network disorder, connectivity analysis may be able to contribute to our understanding of epilepsy and may be potentially developed into clinical applications. In this magnetoencephalographic study, we determined the whole-brain node degree of connectivity levels in patients and controls. Resting-state activity was measured at five frequency bands in 15 healthy controls and 15 patients with focal epilepsy of different etiologies. The whole-brain all-to-all imaginary part of coherence in source space was then calculated. Node degree was determined and parcellated and was used for further statistical evaluation. In comparison to controls, we found a significantly higher overall node degree in patients with lesional and non-lesional epilepsy. Furthermore, we examined the conditions of high/reduced vigilance and open/closed eyes in controls, to analyze whether patient node degree levels can be achieved. We evaluated intraclass-correlation statistics (ICC) to evaluate the reproducibility. Connectivity and specifically node degree analysis could present new tools for one of the most common neurological diseases, with potential applications in epilepsy diagnostics.https://www.mdpi.com/2076-3425/11/12/1590epilepsyepilepsy surgeryepileptogenic focus localizationmagnetencephalographyconnectivitynode degree |
| spellingShingle | Stephan Vogel Martin Kaltenhäuser Cora Kim Nadia Müller-Voggel Karl Rössler Arnd Dörfler Stefan Schwab Hajo Hamer Michael Buchfelder Stefan Rampp MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions Brain Sciences epilepsy epilepsy surgery epileptogenic focus localization magnetencephalography connectivity node degree |
| title | MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions |
| title_full | MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions |
| title_fullStr | MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions |
| title_full_unstemmed | MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions |
| title_short | MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls—Influence of Experimental Conditions |
| title_sort | meg node degree differences in patients with focal epilepsy vs controls influence of experimental conditions |
| topic | epilepsy epilepsy surgery epileptogenic focus localization magnetencephalography connectivity node degree |
| url | https://www.mdpi.com/2076-3425/11/12/1590 |
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