Novel Biological and Technological Platforms for Dental Clinical Use
Human teeth have a limited capacity to regenerate and thus biological reconstruction of damaged or lost dental tissues remains a significant challange in modern dentistry. Recent efforts focus on alternative therapeutic approaches for partial or whole tooth regeneration that complement traditional d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01102/full |
| _version_ | 1818977525482651648 |
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| author | Giovanna Orsini Giovanna Orsini Pierfrancesco Pagella Angelo Putignano Thimios A. Mitsiadis |
| author_facet | Giovanna Orsini Giovanna Orsini Pierfrancesco Pagella Angelo Putignano Thimios A. Mitsiadis |
| author_sort | Giovanna Orsini |
| collection | DOAJ |
| description | Human teeth have a limited capacity to regenerate and thus biological reconstruction of damaged or lost dental tissues remains a significant challange in modern dentistry. Recent efforts focus on alternative therapeutic approaches for partial or whole tooth regeneration that complement traditional dental treatments using sophisticated materials and dental implants. These multidisciplinary approaches are based on the combination of stem cells with advanced tissue engineer products and computing technology, and they hold great promise for future applications in dentistry. The administration to patients of dynamic biological agents composed by stem cells and scaffolds will certainly increase the regenerative capacity of dental pathological tissues. The design of innovative materials for tissue restoration, diagnostics, imaging, and targeted pharmaceutical treatment will significantly improve the quality of dental care and will have a major societal impact. This review depicts the current challenges in dentistry and describes the possibilities for novel and succesful therapeutic applications in the near future. |
| first_indexed | 2024-12-20T16:29:08Z |
| format | Article |
| id | doaj.art-5bb46fd002604893890fc6166dbc7d99 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T16:29:08Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5bb46fd002604893890fc6166dbc7d992022-12-21T19:33:17ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-08-01910.3389/fphys.2018.01102409187Novel Biological and Technological Platforms for Dental Clinical UseGiovanna Orsini0Giovanna Orsini1Pierfrancesco Pagella2Angelo Putignano3Thimios A. Mitsiadis4Orofacial Development and Regeneration, Institute of Oral Biology, Center of Dental Medicine, Faculty of Medicine, University of Zurich, Zurich, SwitzerlandDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, ItalyOrofacial Development and Regeneration, Institute of Oral Biology, Center of Dental Medicine, Faculty of Medicine, University of Zurich, Zurich, SwitzerlandDepartment of Clinical Sciences and Stomatology, Marche Polytechnic University, Ancona, ItalyOrofacial Development and Regeneration, Institute of Oral Biology, Center of Dental Medicine, Faculty of Medicine, University of Zurich, Zurich, SwitzerlandHuman teeth have a limited capacity to regenerate and thus biological reconstruction of damaged or lost dental tissues remains a significant challange in modern dentistry. Recent efforts focus on alternative therapeutic approaches for partial or whole tooth regeneration that complement traditional dental treatments using sophisticated materials and dental implants. These multidisciplinary approaches are based on the combination of stem cells with advanced tissue engineer products and computing technology, and they hold great promise for future applications in dentistry. The administration to patients of dynamic biological agents composed by stem cells and scaffolds will certainly increase the regenerative capacity of dental pathological tissues. The design of innovative materials for tissue restoration, diagnostics, imaging, and targeted pharmaceutical treatment will significantly improve the quality of dental care and will have a major societal impact. This review depicts the current challenges in dentistry and describes the possibilities for novel and succesful therapeutic applications in the near future.https://www.frontiersin.org/article/10.3389/fphys.2018.01102/fulltoothdental treatmentstem cellsorgan-on-chiporganoidsdental implants |
| spellingShingle | Giovanna Orsini Giovanna Orsini Pierfrancesco Pagella Angelo Putignano Thimios A. Mitsiadis Novel Biological and Technological Platforms for Dental Clinical Use Frontiers in Physiology tooth dental treatment stem cells organ-on-chip organoids dental implants |
| title | Novel Biological and Technological Platforms for Dental Clinical Use |
| title_full | Novel Biological and Technological Platforms for Dental Clinical Use |
| title_fullStr | Novel Biological and Technological Platforms for Dental Clinical Use |
| title_full_unstemmed | Novel Biological and Technological Platforms for Dental Clinical Use |
| title_short | Novel Biological and Technological Platforms for Dental Clinical Use |
| title_sort | novel biological and technological platforms for dental clinical use |
| topic | tooth dental treatment stem cells organ-on-chip organoids dental implants |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01102/full |
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