The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review
The initial clinical manifestation of acute mesenteric ischemia poses a diagnostic challenge, often leading to delays in identification and subsequent surgical intervention, contributing to adverse outcomes. Serum biomarkers, offering insights into the underlying pathophysiology, hold promise as pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/7/670 |
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| author | Florin Vasile Mihaileanu Stefan Lucian Popa Simona Grad Dinu Iuliu Dumitrascu Abdulrahman Ismaiel Eliza Rus Vlad Dumitru Brata Alexandru Marius Padureanu Miruna Oana Dita Daria Claudia Turtoi Traian Adrian Duse Andrei Vlad Badulescu Paolo Bottalico Giuseppe Chiarioni Cristina Pop Cristina Mogosan Maria Barsan Claudia Diana Gherman Bogdan Stancu Liliana David |
| author_facet | Florin Vasile Mihaileanu Stefan Lucian Popa Simona Grad Dinu Iuliu Dumitrascu Abdulrahman Ismaiel Eliza Rus Vlad Dumitru Brata Alexandru Marius Padureanu Miruna Oana Dita Daria Claudia Turtoi Traian Adrian Duse Andrei Vlad Badulescu Paolo Bottalico Giuseppe Chiarioni Cristina Pop Cristina Mogosan Maria Barsan Claudia Diana Gherman Bogdan Stancu Liliana David |
| author_sort | Florin Vasile Mihaileanu |
| collection | DOAJ |
| description | The initial clinical manifestation of acute mesenteric ischemia poses a diagnostic challenge, often leading to delays in identification and subsequent surgical intervention, contributing to adverse outcomes. Serum biomarkers, offering insights into the underlying pathophysiology, hold promise as prognostic indicators for acute mesenteric ischemia. This systematic review comprehensively explores the role of blood biomarkers in predicting clinical outcomes during follow-up for patients with mesenteric ischemia. A thorough literature search across the PubMed, Cochrane Library, and EMBASE databases yielded 33 relevant publications investigating the efficacy of serum biomarkers in predicting outcomes for mesenteric ischemia. Numerous studies underscore the utility of blood biomarkers in swiftly and accurately differentiating between causes of mesenteric ischemia, facilitating a prompt diagnosis. Elevated levels of specific biomarkers, particularly D-dimers, consistently correlate with heightened mortality risk and poorer clinical outcomes. While certain serum indicators exhibit substantial potential in associating with mesenteric ischemia, further research through rigorous human trials is imperative to enhance their consistent predictive ability during the follow-up period. This study underscores the diagnostic and prognostic significance of specific biomarkers for mesenteric ischemia, emphasizing the necessity for standardized procedures in future investigations. |
| first_indexed | 2024-04-24T10:47:43Z |
| format | Article |
| id | doaj.art-5bb4f015f9f643048673acd945ec71d8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T10:47:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5bb4f015f9f643048673acd945ec71d82024-04-12T13:16:39ZengMDPI AGDiagnostics2075-44182024-03-0114767010.3390/diagnostics14070670The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic ReviewFlorin Vasile Mihaileanu0Stefan Lucian Popa1Simona Grad2Dinu Iuliu Dumitrascu3Abdulrahman Ismaiel4Eliza Rus5Vlad Dumitru Brata6Alexandru Marius Padureanu7Miruna Oana Dita8Daria Claudia Turtoi9Traian Adrian Duse10Andrei Vlad Badulescu11Paolo Bottalico12Giuseppe Chiarioni13Cristina Pop14Cristina Mogosan15Maria Barsan16Claudia Diana Gherman17Bogdan Stancu18Liliana David19Department of Surgery, County Hospital, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400139 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaDepartment of Anatomy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaDepartment of Medical Sciences, University of Turin, 10126 Turin, ItalyDivision of Gastroenterology B, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Pharmacology, Physiology, and Pathophysiology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Pharmacology, Physiology, and Pathophysiology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Occupational Health, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaDepartment of Surgery-Practical Abilities, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400337 Cluj-Napoca, RomaniaDepartment of Surgery, County Hospital, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400139 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaThe initial clinical manifestation of acute mesenteric ischemia poses a diagnostic challenge, often leading to delays in identification and subsequent surgical intervention, contributing to adverse outcomes. Serum biomarkers, offering insights into the underlying pathophysiology, hold promise as prognostic indicators for acute mesenteric ischemia. This systematic review comprehensively explores the role of blood biomarkers in predicting clinical outcomes during follow-up for patients with mesenteric ischemia. A thorough literature search across the PubMed, Cochrane Library, and EMBASE databases yielded 33 relevant publications investigating the efficacy of serum biomarkers in predicting outcomes for mesenteric ischemia. Numerous studies underscore the utility of blood biomarkers in swiftly and accurately differentiating between causes of mesenteric ischemia, facilitating a prompt diagnosis. Elevated levels of specific biomarkers, particularly D-dimers, consistently correlate with heightened mortality risk and poorer clinical outcomes. While certain serum indicators exhibit substantial potential in associating with mesenteric ischemia, further research through rigorous human trials is imperative to enhance their consistent predictive ability during the follow-up period. This study underscores the diagnostic and prognostic significance of specific biomarkers for mesenteric ischemia, emphasizing the necessity for standardized procedures in future investigations.https://www.mdpi.com/2075-4418/14/7/670mesenteric ischemiabiomarkersclinical outcomesfollow-up |
| spellingShingle | Florin Vasile Mihaileanu Stefan Lucian Popa Simona Grad Dinu Iuliu Dumitrascu Abdulrahman Ismaiel Eliza Rus Vlad Dumitru Brata Alexandru Marius Padureanu Miruna Oana Dita Daria Claudia Turtoi Traian Adrian Duse Andrei Vlad Badulescu Paolo Bottalico Giuseppe Chiarioni Cristina Pop Cristina Mogosan Maria Barsan Claudia Diana Gherman Bogdan Stancu Liliana David The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review Diagnostics mesenteric ischemia biomarkers clinical outcomes follow-up |
| title | The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review |
| title_full | The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review |
| title_fullStr | The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review |
| title_full_unstemmed | The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review |
| title_short | The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review |
| title_sort | efficiency of serum biomarkers in predicting the clinical outcome of patients with mesenteric ischemia during follow up a systematic review |
| topic | mesenteric ischemia biomarkers clinical outcomes follow-up |
| url | https://www.mdpi.com/2075-4418/14/7/670 |
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