Allicin and Cancer Hallmarks
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/6/1320 |
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| author | Wamidh H. Talib Media Mohammed Baban Aya O. Azzam Jenan J. Issa Alaa Y. Ali Alia Kh. AlSuwais Sana Allala Lina T. AL Kury |
| author_facet | Wamidh H. Talib Media Mohammed Baban Aya O. Azzam Jenan J. Issa Alaa Y. Ali Alia Kh. AlSuwais Sana Allala Lina T. AL Kury |
| author_sort | Wamidh H. Talib |
| collection | DOAJ |
| description | Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (<i>Allium sativum</i> L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer. |
| first_indexed | 2024-04-24T17:58:15Z |
| format | Article |
| id | doaj.art-5bb7297ea2d0410393c15ca02fdf8439 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-24T17:58:15Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5bb7297ea2d0410393c15ca02fdf84392024-03-27T13:57:02ZengMDPI AGMolecules1420-30492024-03-01296132010.3390/molecules29061320Allicin and Cancer HallmarksWamidh H. Talib0Media Mohammed Baban1Aya O. Azzam2Jenan J. Issa3Alaa Y. Ali4Alia Kh. AlSuwais5Sana Allala6Lina T. AL Kury7Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, JordanDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab EmiratesNatural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (<i>Allium sativum</i> L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer.https://www.mdpi.com/1420-3049/29/6/1320allicincancer hallmarksanticancerangiogenesismetastasisimmune evasion |
| spellingShingle | Wamidh H. Talib Media Mohammed Baban Aya O. Azzam Jenan J. Issa Alaa Y. Ali Alia Kh. AlSuwais Sana Allala Lina T. AL Kury Allicin and Cancer Hallmarks Molecules allicin cancer hallmarks anticancer angiogenesis metastasis immune evasion |
| title | Allicin and Cancer Hallmarks |
| title_full | Allicin and Cancer Hallmarks |
| title_fullStr | Allicin and Cancer Hallmarks |
| title_full_unstemmed | Allicin and Cancer Hallmarks |
| title_short | Allicin and Cancer Hallmarks |
| title_sort | allicin and cancer hallmarks |
| topic | allicin cancer hallmarks anticancer angiogenesis metastasis immune evasion |
| url | https://www.mdpi.com/1420-3049/29/6/1320 |
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