Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after my...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.863238/full |
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| author | Fahimeh Varzideh Fahimeh Varzideh Urna Kansakar Urna Kansakar Kwame Donkor Scott Wilson Stanislovas S. Jankauskas Stanislovas S. Jankauskas Pasquale Mone Xujun Wang Xujun Wang Angela Lombardi Gaetano Santulli Gaetano Santulli |
| author_facet | Fahimeh Varzideh Fahimeh Varzideh Urna Kansakar Urna Kansakar Kwame Donkor Scott Wilson Stanislovas S. Jankauskas Stanislovas S. Jankauskas Pasquale Mone Xujun Wang Xujun Wang Angela Lombardi Gaetano Santulli Gaetano Santulli |
| author_sort | Fahimeh Varzideh |
| collection | DOAJ |
| description | After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields. |
| first_indexed | 2024-12-12T21:43:23Z |
| format | Article |
| id | doaj.art-5bb783d0d36d412ba5d5301a16704adf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T21:43:23Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5bb783d0d36d412ba5d5301a16704adf2022-12-22T00:10:59ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.863238863238Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and FibrosisFahimeh Varzideh0Fahimeh Varzideh1Urna Kansakar2Urna Kansakar3Kwame Donkor4Scott Wilson5Stanislovas S. Jankauskas6Stanislovas S. Jankauskas7Pasquale Mone8Xujun Wang9Xujun Wang10Angela Lombardi11Gaetano Santulli12Gaetano Santulli13Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United StatesDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United StatesAfter an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.https://www.frontiersin.org/articles/10.3389/fcvm.2022.863238/fullcardiac remodelingclinical trialsdrug developmentepigeneticsheart failureischemic heart disease |
| spellingShingle | Fahimeh Varzideh Fahimeh Varzideh Urna Kansakar Urna Kansakar Kwame Donkor Scott Wilson Stanislovas S. Jankauskas Stanislovas S. Jankauskas Pasquale Mone Xujun Wang Xujun Wang Angela Lombardi Gaetano Santulli Gaetano Santulli Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis Frontiers in Cardiovascular Medicine cardiac remodeling clinical trials drug development epigenetics heart failure ischemic heart disease |
| title | Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis |
| title_full | Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis |
| title_fullStr | Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis |
| title_full_unstemmed | Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis |
| title_short | Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis |
| title_sort | cardiac remodeling after myocardial infarction functional contribution of micrornas to inflammation and fibrosis |
| topic | cardiac remodeling clinical trials drug development epigenetics heart failure ischemic heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.863238/full |
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