Inhibition of rat locus coeruleus neurons by prostaglandin E2 EP3 receptors: pharmacological characterization ex vivo

Inhibition of rat locus coeruleus neurons by prostaglandin E2 EP3 receptors: pharmacological characterization ex vivo

Prostaglandin E2 (PGE2) is an inflammatory mediator synthesized by the brain constitutive cyclooxygenase enzyme. PGE2 binds to G protein-coupled EP1-4 receptors (EP1 to Gq, EP2,4 to Gs, and EP3 to Gi/o). EP2, EP3 and EP4 receptors are expressed in the locus coeruleus (LC), the main noradrenergic nuc...

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Bibliographic Details
Main Authors:	Amaia Nazabal, Aitziber Mendiguren, Joseba Pineda
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Series:	Frontiers in Pharmacology
Subjects:	locus coeruleus prostanoid EP3 receptor prostaglandin E2 noradrenaline/norepinephrine slice electrophysiology
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1290605/full

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