Baroreflex Dysfunction in Prader Willi Syndrome
Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity and mortality - which could probably be attributed to autonomic dysfunction. A 21-year-old Prader Willi syndrome patient was referred for cardiovascular and aut...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/7410/17064_CE[Ra1]_F(GH)_PF1(Vi_Om)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1811294126532984832 |
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| author | Manpreet Kaur Shival Srivastav Ashok Kumar Jaryal Kishore Kumar Deepak |
| author_facet | Manpreet Kaur Shival Srivastav Ashok Kumar Jaryal Kishore Kumar Deepak |
| author_sort | Manpreet Kaur |
| collection | DOAJ |
| description | Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity
and mortality - which could probably be attributed to autonomic dysfunction. A 21-year-old Prader Willi syndrome patient was referred
for cardiovascular and autonomic function assessment. We performed a battery of tests assessing vascular structure (carotid intima
thickness), vascular function (arterial stiffness indices), baroreflex sensitivity (overall integrator of short term regulation of blood pressure),
blood pressure variability and autonomic tone (heart rate variability) along with autonomic reactivity tests. We observed impaired
baroreflex sensitivity along with orthostatic tachycardia with normal vascular function tests. Prader- Willi syndrome patient have baroreflex
dysfunction with probable afferent and/ central autonomic neural defects. |
| first_indexed | 2024-04-13T05:12:51Z |
| format | Article |
| id | doaj.art-5bba9f79e1434598bb15a4fbde7bb2ad |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T05:12:51Z |
| publishDate | 2016-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5bba9f79e1434598bb15a4fbde7bb2ad2022-12-22T03:00:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-03-01103CD01CD0210.7860/JCDR/2016/17064.7410Baroreflex Dysfunction in Prader Willi SyndromeManpreet Kaur0Shival Srivastav1Ashok Kumar Jaryal2Kishore Kumar Deepak3Senior Demonstrator, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.Junior Demonstrator, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.Professor, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.Professor, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity and mortality - which could probably be attributed to autonomic dysfunction. A 21-year-old Prader Willi syndrome patient was referred for cardiovascular and autonomic function assessment. We performed a battery of tests assessing vascular structure (carotid intima thickness), vascular function (arterial stiffness indices), baroreflex sensitivity (overall integrator of short term regulation of blood pressure), blood pressure variability and autonomic tone (heart rate variability) along with autonomic reactivity tests. We observed impaired baroreflex sensitivity along with orthostatic tachycardia with normal vascular function tests. Prader- Willi syndrome patient have baroreflex dysfunction with probable afferent and/ central autonomic neural defects.https://jcdr.net/articles/PDF/7410/17064_CE[Ra1]_F(GH)_PF1(Vi_Om)_PFA(AK)_PF2(PAG).pdfarterial stiffnessautonomic dysfunctioncarotid intima thickness |
| spellingShingle | Manpreet Kaur Shival Srivastav Ashok Kumar Jaryal Kishore Kumar Deepak Baroreflex Dysfunction in Prader Willi Syndrome Journal of Clinical and Diagnostic Research arterial stiffness autonomic dysfunction carotid intima thickness |
| title | Baroreflex Dysfunction in Prader Willi Syndrome |
| title_full | Baroreflex Dysfunction in Prader Willi Syndrome |
| title_fullStr | Baroreflex Dysfunction in Prader Willi Syndrome |
| title_full_unstemmed | Baroreflex Dysfunction in Prader Willi Syndrome |
| title_short | Baroreflex Dysfunction in Prader Willi Syndrome |
| title_sort | baroreflex dysfunction in prader willi syndrome |
| topic | arterial stiffness autonomic dysfunction carotid intima thickness |
| url | https://jcdr.net/articles/PDF/7410/17064_CE[Ra1]_F(GH)_PF1(Vi_Om)_PFA(AK)_PF2(PAG).pdf |
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