A computational model of liver tissue damage and repair.

A computational model of liver tissue damage and repair.

Drug induced liver injury (DILI) and cell death can result from oxidative stress in hepatocytes. An initial pattern of centrilobular damage in the APAP model of DILI is amplified by communication from stressed cells and immune system activation. While hepatocyte proliferation counters cell loss, hig...

Full description

Bibliographic Details
Main Authors: Priyom Adhyapok, Xiao Fu, James P Sluka, Sherry G Clendenon, Victoria D Sluka, Zemin Wang, Kenneth Dunn, James E Klaunig, James A Glazier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0243451

Similar Items

Similar Items