Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis
Background and objectivePrevious studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1175477/full |
| _version_ | 1827949655515725824 |
|---|---|
| author | Xu Jing Wen Zhuyuan Wen Zhuyuan Chen Aijun Xiong Jianxia Huang Kun Wang Ping |
| author_facet | Xu Jing Wen Zhuyuan Wen Zhuyuan Chen Aijun Xiong Jianxia Huang Kun Wang Ping |
| author_sort | Xu Jing |
| collection | DOAJ |
| description | Background and objectivePrevious studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with psoriasis and non-psoriatic controls are limited and inconsistent. The aim of this study was to carry out a comparison of the probability of suffering CKD and ESRD in patients with or without psoriasis by conducting a meta-analysis of cohort studies.MethodsCohort studies on PubMed, Web of Science, Embase and Cochrane Library by March, 2023 were searched for. The studies were screened according to pre-established inclusion criteria. Hazard ratios (HRs) and a 95% confidence intervals (CIs) for the renal outcomes among patients with psoriasis were calculated using the random-effect, generic inverse variance method. Subgroup analysis was related to the severity of psoriasis.ResultsA total of seven retrospective cohort studies were included, including 738,104 psoriasis patients and 3,443,438 non-psoriasis subjects, published from 2013 to 2020. Compared to controls without psoriasis, patients with psoriasis had an increased risk of CKD and ESRD, with pooled hazard ratios of 1.65 (95% CI, 1.29–2.12) and 1.37 (95% CI, 1.14–1.64), respectively. Besides, the incidence of CKD and ESRD is positively correlated with the severity of psoriasis.ConclusionThis study showed that compared to patients without psoriasis, patients with psoriasis, especially those with severe psoriasis, had a significantly increased risk of developing CKD and ESRD. Considering the limitations of this meta-analysis, more high-quality and well-designed studies are needed in the future to validate our findings. |
| first_indexed | 2024-04-09T13:13:21Z |
| format | Article |
| id | doaj.art-5bbbb676aa684f69b0cdb7c9d622297d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T13:13:21Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5bbbb676aa684f69b0cdb7c9d622297d2023-05-12T05:40:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11754771175477Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysisXu Jing0Wen Zhuyuan1Wen Zhuyuan2Chen Aijun3Xiong Jianxia4Huang Kun5Wang Ping6Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaCollege of Pediatrics, Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackground and objectivePrevious studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with psoriasis and non-psoriatic controls are limited and inconsistent. The aim of this study was to carry out a comparison of the probability of suffering CKD and ESRD in patients with or without psoriasis by conducting a meta-analysis of cohort studies.MethodsCohort studies on PubMed, Web of Science, Embase and Cochrane Library by March, 2023 were searched for. The studies were screened according to pre-established inclusion criteria. Hazard ratios (HRs) and a 95% confidence intervals (CIs) for the renal outcomes among patients with psoriasis were calculated using the random-effect, generic inverse variance method. Subgroup analysis was related to the severity of psoriasis.ResultsA total of seven retrospective cohort studies were included, including 738,104 psoriasis patients and 3,443,438 non-psoriasis subjects, published from 2013 to 2020. Compared to controls without psoriasis, patients with psoriasis had an increased risk of CKD and ESRD, with pooled hazard ratios of 1.65 (95% CI, 1.29–2.12) and 1.37 (95% CI, 1.14–1.64), respectively. Besides, the incidence of CKD and ESRD is positively correlated with the severity of psoriasis.ConclusionThis study showed that compared to patients without psoriasis, patients with psoriasis, especially those with severe psoriasis, had a significantly increased risk of developing CKD and ESRD. Considering the limitations of this meta-analysis, more high-quality and well-designed studies are needed in the future to validate our findings.https://www.frontiersin.org/articles/10.3389/fmed.2023.1175477/fullpsoriasischronic kidney disease (CKD)end-stage renal disease (ESRD)renal injurymeta-analysis |
| spellingShingle | Xu Jing Wen Zhuyuan Wen Zhuyuan Chen Aijun Xiong Jianxia Huang Kun Wang Ping Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis Frontiers in Medicine psoriasis chronic kidney disease (CKD) end-stage renal disease (ESRD) renal injury meta-analysis |
| title | Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis |
| title_full | Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis |
| title_fullStr | Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis |
| title_full_unstemmed | Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis |
| title_short | Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis |
| title_sort | association of psoriasis with chronic kidney disease and end stage renal disease a systematic review and meta analysis |
| topic | psoriasis chronic kidney disease (CKD) end-stage renal disease (ESRD) renal injury meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1175477/full |
| work_keys_str_mv | AT xujing associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT wenzhuyuan associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT wenzhuyuan associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT chenaijun associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT xiongjianxia associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT huangkun associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis AT wangping associationofpsoriasiswithchronickidneydiseaseandendstagerenaldiseaseasystematicreviewandmetaanalysis |