Design, Synthesis, and Biological Evaluation of N-Acyl-Homoserine Lactone Analogs of Quorum Sensing in Pseudomonas aeruginosa

Design, Synthesis, and Biological Evaluation of N-Acyl-Homoserine Lactone Analogs of Quorum Sensing in Pseudomonas aeruginosa

Quorum sensing plays a necessary role in the production of virulence factors and the formation of biofilm on Pseudomonas aeruginosa. Thus, the development of inhibition of quorum sensing is one of the most promising methods to control bacterial infection and antibiotic resistance. In this work, nine...

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Bibliographic Details
Main Authors: Zhenyu Wei, Ting Li, Yan Gu, Qian Zhang, Enhui Wang, Wenbo Li, Xin Wang, Yang Li, Hongyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Chemistry
Subjects:
AHL analogs
quorum sensing
Pseudomonas aeruginosa
anti-virulence
antibiofilm
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.948687/full

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