Screening dataset of food components that enhance transcriptional activity of PGC1-beta
PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measur...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340919301659 |
| _version_ | 1828487592352415744 |
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| author | Shiho Nakai Ran Uchitomi Rintaro Matsuda Takumi Onishi Yukino Hatazawa Yasutomi Kamei |
| author_facet | Shiho Nakai Ran Uchitomi Rintaro Matsuda Takumi Onishi Yukino Hatazawa Yasutomi Kamei |
| author_sort | Shiho Nakai |
| collection | DOAJ |
| description | PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β.We found that soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β, see “Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression” [1]. The list of 166 compounds and their reporter activity is shown here. Keywords: Screening, Reporter assay, Transcriptional activity |
| first_indexed | 2024-12-11T09:53:35Z |
| format | Article |
| id | doaj.art-5bbc449fbc9d409281f5bb4f1fb3ef41 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T09:53:35Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-5bbc449fbc9d409281f5bb4f1fb3ef412022-12-22T01:12:19ZengElsevierData in Brief2352-34092019-04-0123Screening dataset of food components that enhance transcriptional activity of PGC1-betaShiho Nakai0Ran Uchitomi1Rintaro Matsuda2Takumi Onishi3Yukino Hatazawa4Yasutomi Kamei5Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanCorresponding author.; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanPGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β.We found that soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β, see “Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression” [1]. The list of 166 compounds and their reporter activity is shown here. Keywords: Screening, Reporter assay, Transcriptional activityhttp://www.sciencedirect.com/science/article/pii/S2352340919301659 |
| spellingShingle | Shiho Nakai Ran Uchitomi Rintaro Matsuda Takumi Onishi Yukino Hatazawa Yasutomi Kamei Screening dataset of food components that enhance transcriptional activity of PGC1-beta Data in Brief |
| title | Screening dataset of food components that enhance transcriptional activity of PGC1-beta |
| title_full | Screening dataset of food components that enhance transcriptional activity of PGC1-beta |
| title_fullStr | Screening dataset of food components that enhance transcriptional activity of PGC1-beta |
| title_full_unstemmed | Screening dataset of food components that enhance transcriptional activity of PGC1-beta |
| title_short | Screening dataset of food components that enhance transcriptional activity of PGC1-beta |
| title_sort | screening dataset of food components that enhance transcriptional activity of pgc1 beta |
| url | http://www.sciencedirect.com/science/article/pii/S2352340919301659 |
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