Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats
Maternal Porphyromonasgingivalis infection on periodontal tissue can result in Porphyromonasgingivalis dissemination to umbillical cord. Porphyromonas gingivalis presumably gain access to the systemic circulation via local tissue inflammation, and may affect the placental development and the fetus i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Muhammadiyah Yogyakarta
2014-01-01
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| Series: | Insisiva Dental Journal |
| Subjects: | |
| Online Access: | https://journal.umy.ac.id/index.php/di/article/view/1725 |
| _version_ | 1817977782261514240 |
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| author | Banun Kusumawardani Yuliana MD Arina Azham Purwandhono |
| author_facet | Banun Kusumawardani Yuliana MD Arina Azham Purwandhono |
| author_sort | Banun Kusumawardani |
| collection | DOAJ |
| description | Maternal Porphyromonasgingivalis infection on periodontal tissue can result in Porphyromonasgingivalis
dissemination to umbillical cord. Porphyromonas gingivalis presumably gain access to the systemic circulation
via local tissue inflammation, and may affect the placental development and the fetus itself. This study aimed to
analize the effect of periodontal infection with Porphyromonas gingivalis on placental development, and to
determine its effect on fetal growth in a pregnant rat model. Female rats were infected with live-Porphyromonas
gingivalis at concentration of 2x109 cells/ml into subgingival sulcus of the maxillary first molar before and/or
during pregnancy. They were sacrified on gestational day (GD) 20. Fetuses were evaluated for weight and
length. All placentas were fixed in 10% buffered formalin, processed for paraffin embedding, and stained with
hematoxylin and eosin.The histopathological analysis of placentas on GD 20 showed that trophoblast cells in
labyrinth and junctional zone had a greater density in control group than Porphyromonas gingivalis-infected
periodontal maternal group. The nucleated-erythrocytes were found more abundant in the fetal blood vessels of
Porphyromonas gingivalis-infected periodontal maternal group than in the fetal blood vessels of control group.
In conclusion, the impaired placental morphology influenced the normal function of placenta to maintain the
growth and development of fetus. The decreased placental weightresulted in the decreased of fetal weight
andlength. |
| first_indexed | 2024-04-13T22:21:04Z |
| format | Article |
| id | doaj.art-5bbcb1ea07d64888b078f2db8d58b187 |
| institution | Directory Open Access Journal |
| issn | 2252-9764 2685-9165 |
| language | English |
| last_indexed | 2024-04-13T22:21:04Z |
| publishDate | 2014-01-01 |
| publisher | Universitas Muhammadiyah Yogyakarta |
| record_format | Article |
| series | Insisiva Dental Journal |
| spelling | doaj.art-5bbcb1ea07d64888b078f2db8d58b1872022-12-22T02:27:14ZengUniversitas Muhammadiyah YogyakartaInsisiva Dental Journal2252-97642685-91652014-01-0131222910.18196/di.v3i1.17251486Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant RatsBanun Kusumawardani0Yuliana MD Arina1Azham Purwandhono2Universitas JemberUniversitas JemberUniversitas JemberMaternal Porphyromonasgingivalis infection on periodontal tissue can result in Porphyromonasgingivalis dissemination to umbillical cord. Porphyromonas gingivalis presumably gain access to the systemic circulation via local tissue inflammation, and may affect the placental development and the fetus itself. This study aimed to analize the effect of periodontal infection with Porphyromonas gingivalis on placental development, and to determine its effect on fetal growth in a pregnant rat model. Female rats were infected with live-Porphyromonas gingivalis at concentration of 2x109 cells/ml into subgingival sulcus of the maxillary first molar before and/or during pregnancy. They were sacrified on gestational day (GD) 20. Fetuses were evaluated for weight and length. All placentas were fixed in 10% buffered formalin, processed for paraffin embedding, and stained with hematoxylin and eosin.The histopathological analysis of placentas on GD 20 showed that trophoblast cells in labyrinth and junctional zone had a greater density in control group than Porphyromonas gingivalis-infected periodontal maternal group. The nucleated-erythrocytes were found more abundant in the fetal blood vessels of Porphyromonas gingivalis-infected periodontal maternal group than in the fetal blood vessels of control group. In conclusion, the impaired placental morphology influenced the normal function of placenta to maintain the growth and development of fetus. The decreased placental weightresulted in the decreased of fetal weight andlength.https://journal.umy.ac.id/index.php/di/article/view/1725porphyromonasgingivalisperiodontitispregnancyplacental developmentfetal growth |
| spellingShingle | Banun Kusumawardani Yuliana MD Arina Azham Purwandhono Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats Insisiva Dental Journal porphyromonasgingivalis periodontitis pregnancy placental development fetal growth |
| title | Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats |
| title_full | Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats |
| title_fullStr | Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats |
| title_full_unstemmed | Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats |
| title_short | Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats |
| title_sort | perkembangan plasenta dan pertumbuhan janin pada tikus hamil yang diinfeksi porphyromonas gingivalis placental development and fetal growth in porphyromonas gingivalis infected pregnant rats |
| topic | porphyromonasgingivalis periodontitis pregnancy placental development fetal growth |
| url | https://journal.umy.ac.id/index.php/di/article/view/1725 |
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