Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress

Hyperuricemia (HUA)-induced oxidative stress is a crucial contributor to hyperuricemic nephropathy (HN), but the molecular mechanisms underlying the disturbed redox homeostasis in kidneys remain elusive. Using RNA sequencing, together with biochemical analyses, we found that nuclear factor erythroid...

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Bibliographic Details
Main Authors: Panshuang Qiao, Yi Sun, Yiming Wang, Simei Lin, Yongpan An, Liang Wang, Jihan Liu, Yajun Huang, Baoxue Yang, Hong Zhou
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
hyperuricemic nephropathy
NRF2
oxidative stress
mitochondria
chronic kidney disease
tubulointerstitial fibrosis
Online Access:https://www.mdpi.com/2076-3921/12/5/1022

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