The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats
<p>Abstract</p> <p>In the present study, the effects of subchronic treatments (4 weeks) of hypercholesterolemic (single) and diabetic-hypercholesterolemic (combined) rats with 4 (3H) quinazolinone and 2 halogenated derivatives (6, 8-dibromo-2-methy-4 (3H) quinazolinone and 6-iodo-2...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-10-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/4/1/22 |
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| author | Ibrahim Aida M Gawad Soad Esmat Amr Y Refaie Fawzia M Mohamed Mona A |
| author_facet | Ibrahim Aida M Gawad Soad Esmat Amr Y Refaie Fawzia M Mohamed Mona A |
| author_sort | Ibrahim Aida M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In the present study, the effects of subchronic treatments (4 weeks) of hypercholesterolemic (single) and diabetic-hypercholesterolemic (combined) rats with 4 (3H) quinazolinone and 2 halogenated derivatives (6, 8-dibromo-2-methy-4 (3H) quinazolinone and 6-iodo-2-methyl-4(3H) quinazolinone) at a sublethal dose level (2 mg/Kg) on cholesterol metabolism were investigated. Bezafibrate, a hypolipidemic drug was used as a reference compound for data comparison. Treatment of rats with single and combined hypercholesterolemia with quinazolinone compounds gave rise to highly significant reductions in serum total cholesterol and cholesterol ester levels, whereas serum triacylglycerol level was significantly reduced only after treatment with halogen-substituted quinazolinones in single hyper-cholesterolemia, compared to the control group. The effects of different quinazolinones and bezafibrate on reduction of serum LDL-C level were comparable in single hypercholesterolemia but significantly different in combined hypercholesterolemia. Results obtained from this study suggest that the antihyperlipidemic effect of quinazolinone compounds was brought about by inhibition of dietary cholesterol absorption and / or intestinal ACAT activity.</p> |
| first_indexed | 2024-12-17T06:19:18Z |
| format | Article |
| id | doaj.art-5bc2dd138fb248d49f0033b68e5b0015 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-17T06:19:18Z |
| publishDate | 2005-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-5bc2dd138fb248d49f0033b68e5b00152022-12-21T22:00:27ZengBMCLipids in Health and Disease1476-511X2005-10-01412210.1186/1476-511X-4-22The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in ratsIbrahim Aida MGawad SoadEsmat Amr YRefaie Fawzia MMohamed Mona A<p>Abstract</p> <p>In the present study, the effects of subchronic treatments (4 weeks) of hypercholesterolemic (single) and diabetic-hypercholesterolemic (combined) rats with 4 (3H) quinazolinone and 2 halogenated derivatives (6, 8-dibromo-2-methy-4 (3H) quinazolinone and 6-iodo-2-methyl-4(3H) quinazolinone) at a sublethal dose level (2 mg/Kg) on cholesterol metabolism were investigated. Bezafibrate, a hypolipidemic drug was used as a reference compound for data comparison. Treatment of rats with single and combined hypercholesterolemia with quinazolinone compounds gave rise to highly significant reductions in serum total cholesterol and cholesterol ester levels, whereas serum triacylglycerol level was significantly reduced only after treatment with halogen-substituted quinazolinones in single hyper-cholesterolemia, compared to the control group. The effects of different quinazolinones and bezafibrate on reduction of serum LDL-C level were comparable in single hypercholesterolemia but significantly different in combined hypercholesterolemia. Results obtained from this study suggest that the antihyperlipidemic effect of quinazolinone compounds was brought about by inhibition of dietary cholesterol absorption and / or intestinal ACAT activity.</p>http://www.lipidworld.com/content/4/1/22QuinazolinoneHalogenated quinazolinonesBezafibratehypercholesterolemiaDiabetes mellitusTriglyceridesCholesterollipoproteinsRat |
| spellingShingle | Ibrahim Aida M Gawad Soad Esmat Amr Y Refaie Fawzia M Mohamed Mona A The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats Lipids in Health and Disease Quinazolinone Halogenated quinazolinones Bezafibrate hypercholesterolemia Diabetes mellitus Triglycerides Cholesterol lipoproteins Rat |
| title | The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats |
| title_full | The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats |
| title_fullStr | The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats |
| title_full_unstemmed | The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats |
| title_short | The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats |
| title_sort | antihyperlipidemic activities of 4 3h quinazolinone and two halogenated derivatives in rats |
| topic | Quinazolinone Halogenated quinazolinones Bezafibrate hypercholesterolemia Diabetes mellitus Triglycerides Cholesterol lipoproteins Rat |
| url | http://www.lipidworld.com/content/4/1/22 |
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