Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA
Purpose: To measure multi-quantum coherence (MQC) 23Na signals for noninvasive cell physiological information in the whole-brain, the 2D-CRISTINA method was extended to 3D. This experimental study investigated the use and results of a new sequence, 3D-CRISTINA, on a phantom and healthy volunteers. M...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Zeitschrift für Medizinische Physik |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0939388921000830 |
| _version_ | 1797385280321224704 |
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| author | Michaela A.U. Hoesl Lothar R. Schad Stanislas Rapacchi |
| author_facet | Michaela A.U. Hoesl Lothar R. Schad Stanislas Rapacchi |
| author_sort | Michaela A.U. Hoesl |
| collection | DOAJ |
| description | Purpose: To measure multi-quantum coherence (MQC) 23Na signals for noninvasive cell physiological information in the whole-brain, the 2D-CRISTINA method was extended to 3D. This experimental study investigated the use and results of a new sequence, 3D-CRISTINA, on a phantom and healthy volunteers. Methods: The 3D Cartesian single and triple-quantum imaging of 23Na (3D-CRISTINA) was developed and implemented at 7T, favoring a non-selective volume excitation for increased signal-to-noise ratio (SNR) and lower energy deployment than its 2D counterpart. Two independent phase cycles were used in analogy to the 2D method. A comparison of 6-steps cycles and 12-steps cycles was performed.We used a phantom composed of different sodium and agarose concentrations, 50 mM to 150 mM Na+, and 0–5% agarose for sequence validation. Four healthy volunteers were scanned at 7T for whole brain MQC imaging. The sequence 3D-CRISTINA was developed and tested at 7T. Results: At 7T, the 3D-CRISTINA acquisition allowed to reduce the TR to 230 ms from the previous 390 ms for 2D, resulting in a total acquisition time of 53 min for a 3D volume of 4 × 4 × 8 mm resolution. The phase cycle evaluation showed that the 7T acquisition time could be reduced by 4-fold with moderate single and triple-quantum signals SNR loss. The healthy volunteers demonstrated clinical feasibility at 7T and showed a difference in the MQC signals ratio of White Matter (WM) and Grey Matter (GM). Conclusion: Volumetric CRISTINA multi-quantum imaging allowed whole-brain coverage. The non-selective excitation enabled a faster scan due to a decrease in energy deposition which enabled a lower repetition time. Thus, it should be the preferred choice for future in vivo multi-quantum applications compared to the 2D method. A more extensive study is warranted to explore WM and GM MQC differences. |
| first_indexed | 2024-03-08T21:51:54Z |
| format | Article |
| id | doaj.art-5bc36859eab742a1a1cdf92ac7e822fc |
| institution | Directory Open Access Journal |
| issn | 0939-3889 |
| language | English |
| last_indexed | 2024-03-08T21:51:54Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Zeitschrift für Medizinische Physik |
| spelling | doaj.art-5bc36859eab742a1a1cdf92ac7e822fc2023-12-20T07:33:10ZengElsevierZeitschrift für Medizinische Physik0939-38892022-05-01322199208Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINAMichaela A.U. Hoesl0Lothar R. Schad1Stanislas Rapacchi2Computer Assisted Clinical Medicine, Heidelberg University, 68167 Mannheim, Germany; Corresponding author: Michaela A.U. Hoesl, Computer Assisted Clinical Medicine, Heidelberg University, 68167 Mannheim, Germany.Computer Assisted Clinical Medicine, Heidelberg University, 68167 Mannheim, GermanyAix-Marseille Univ, CNRS, CRMBM, Marseille, FrancePurpose: To measure multi-quantum coherence (MQC) 23Na signals for noninvasive cell physiological information in the whole-brain, the 2D-CRISTINA method was extended to 3D. This experimental study investigated the use and results of a new sequence, 3D-CRISTINA, on a phantom and healthy volunteers. Methods: The 3D Cartesian single and triple-quantum imaging of 23Na (3D-CRISTINA) was developed and implemented at 7T, favoring a non-selective volume excitation for increased signal-to-noise ratio (SNR) and lower energy deployment than its 2D counterpart. Two independent phase cycles were used in analogy to the 2D method. A comparison of 6-steps cycles and 12-steps cycles was performed.We used a phantom composed of different sodium and agarose concentrations, 50 mM to 150 mM Na+, and 0–5% agarose for sequence validation. Four healthy volunteers were scanned at 7T for whole brain MQC imaging. The sequence 3D-CRISTINA was developed and tested at 7T. Results: At 7T, the 3D-CRISTINA acquisition allowed to reduce the TR to 230 ms from the previous 390 ms for 2D, resulting in a total acquisition time of 53 min for a 3D volume of 4 × 4 × 8 mm resolution. The phase cycle evaluation showed that the 7T acquisition time could be reduced by 4-fold with moderate single and triple-quantum signals SNR loss. The healthy volunteers demonstrated clinical feasibility at 7T and showed a difference in the MQC signals ratio of White Matter (WM) and Grey Matter (GM). Conclusion: Volumetric CRISTINA multi-quantum imaging allowed whole-brain coverage. The non-selective excitation enabled a faster scan due to a decrease in energy deposition which enabled a lower repetition time. Thus, it should be the preferred choice for future in vivo multi-quantum applications compared to the 2D method. A more extensive study is warranted to explore WM and GM MQC differences.http://www.sciencedirect.com/science/article/pii/S0939388921000830Sodium MRISodium triple-quantum imagingWhole-brain imaging |
| spellingShingle | Michaela A.U. Hoesl Lothar R. Schad Stanislas Rapacchi Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA Zeitschrift für Medizinische Physik Sodium MRI Sodium triple-quantum imaging Whole-brain imaging |
| title | Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA |
| title_full | Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA |
| title_fullStr | Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA |
| title_full_unstemmed | Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA |
| title_short | Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA |
| title_sort | volumetric 23na single and triple quantum imaging at 7t 3d cristina |
| topic | Sodium MRI Sodium triple-quantum imaging Whole-brain imaging |
| url | http://www.sciencedirect.com/science/article/pii/S0939388921000830 |
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